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Completed

NCT Number: NCT04865003

Prognostic Factors for Descending Necrotizing Mediastinitis Development in Deep Space Neck Infections

Descending necrotizing mediastinitis (DNM) is the most serious complication of deep neck infections (DNI) with high mortality. The objective of this retrospective study was to evaluate possible prognostic factors for DNM development in deep space neck infections.

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Key information

Conditions

Infection Infections Inflammation Mediastinal Diseases Mediastinitis Neck Abscess Pathologic Processes Pathological Conditions, Signs and Symptoms Respiratory Tract Diseases Thoracic Diseases

Sex eligibility

All sexes

Study type

Observational

About this study

Descending necrotizing mediastinitis (DNM) is the most serious complication of deep neck infections (DNI) with high mortality. The objective of this retrospective study was to evaluate possible prognostic factors for DNM development in deep space neck infections. The study enrolled patients admitted to the Emergency Center of Vojvodina with the diagnosis of multispace DNI with or without DNM either as the primary diagnosis or with discharged diagnosis after surgical treatment during 7-years period. The data were obtained from patient medical records.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • patients admitted to the hospital due to deep neck infection affecting two or more spaces with or without descending necrotizing medioastinitis
  • complete diagnosis and treatment data available from medical charts

Exclusion criteria

  • incomplete medical data
  • infection confined to one deep neck space
  • patients treated under local anesthesia
  • patients with superficial skin infections
  • iatrogenic infections
  • infected tumors

Treatment and study plan

treatment of infection

Other

Primary outcomes

  1. Incidence of mediastinitis

    Time frame: Within 6 hours of admission

    Neck and chest computed tomography (CT)

Secondary outcomes

  1. Microbiological findings in DNI and DNM

    Time frame: Within 1 week of admission

    Prevalence of microorganisms in mediastinitis

  2. Average number of hospital days

    Time frame: Through study completion, an average of one month

    Comparison of average number of hospital days in DNI and DNM

  3. Incidence of complications

    Time frame: Within 30 days from admission

    Complications among DNI and DNI+DNM groups

  4. Number of infected deep neck spaces

    Time frame: Within 6 hours of admission

    Neck and chest computed tomography (CT)

Sponsors and collaborators

Lead sponsor

Clinical Center of Vojvodina

Other

Registry information

Official study title

Prognostic Factors for Descending Necrotizing Mediastinitis Development in Deep Space Neck Infections - A Retrospective Study

Important dates

Study start
2014
Primary completion
2020
Study completion
2020
First posted
Apr 29, 2021
Registry last updated
Apr 29, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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