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NCT Number: NCT03350802

Procalcitonin Test for Differentiation of the Cause of Pneumonia

The purpose of this study is to evaluate the usefulness of procalcitonin test for differentiation of the cause of pneumonia in patients with cancer.

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Key information

Conditions

Procalcitonin Cancer Infections Lung Diseases Neoplasms Pneumonia Respiratory Tract Diseases Respiratory Tract Infections

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Respiratory Clinic, National Cancer Center

Goyang-si, Gyeonggi-do, 410-769, South Korea

About this study

Serum procalcitonin test is currently used as the biomarker for bacterial infection. Especially, procalcitonin test has been reported to be helpful in differentiating bacterial pneumonia from viral pneumonia, acute exacerbations of interstitial pneumonitis or chronic obstructive lung disease. However, it is not known whether procalcitonin test can help distinguish bacterial pneumonia from non-bacterial pneumonia such as radiation pneumonitis or chemotherapy-induced pneumonitis in patients with cancer.

The aim of this prospective cohort study is to observe the clinical benefits of procalcitonin test for differentiation of the cause of pneumonia in patients with cancer.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age greater than 18 years
  • Patients who have symptoms and suspected imaging findings compatible with pneumonia

Exclusion criteria

  • Patients who have been treated with antibiotics or steroid therapy.

Treatment and study plan

procalcitonin test

Diagnostic Test

All patients enrolled in this cohort undergo procalcitonin test in addition to basic microbiological test.

Primary outcomes

  1. Procalcitonin level according to the cause of pneumonia in patients with cancer

    Time frame: procalcitonin level is checked within 24hours after visiting hospital

    bacterial pneumonia vs. radiation pneumonitis vs chemotherapy-induced pneumonitis

Secondary outcomes

  1. Influence of neutropenia on procalcitonin level in patients with baterial pneumonia

    Time frame: procalcitonin level is checked within 24hours after visiting hospital

    bacterial pneumonia with neutropenia vs. without neutropenia

  2. procalcitonin level in patients with atypical pneumonia

    Time frame: procalcitonin level is checked within 24hours after visiting hospital

    viral pneumonia vs tuberculosis vs fungal infection

Sponsors and collaborators

Lead sponsor

National Cancer Center, Korea

Other Gov

Registry information

Official study title

Usefulness of Procalcitonin Test to Differentiate the Cause of Pneumonia in Patients With Cancers

Important dates

Study start
2014
Primary completion
2020
Study completion
2020
First posted
Nov 22, 2017
Registry last updated
Sep 25, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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