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Completed

NCT Number: NCT06958354

Evaluation of the Clinical Relationship Between Procalcitonin Level and Bacteremia Agent in Intensive Care Unit Patients

In intensive care units, sepsis, which can be defined as bacteremia and the irregular and uncontrolled inflammatory response to it, is one of the most important causes of mortality. Early recognition of sepsis and appropriate antibiotic use for the causative agent is one of the most important steps in the fight against sepsis. Procalcitonin (PCT) is a calcitonin precursor peptide and has been reported to predict bacteremia early. While the PCT concentration level is negligible in healthy individuals, it has been shown to increase especially in bacterial infections, sepsis, trauma and burns. In our study, our aim is to determine whether there is a relationship between serum PCT concentration levels taken within 24 hours according to the time of the sample taken for blood culture with growth in patients followed up in our Internal Intensive Care Unit.

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Key information

Conditions

Sepsis Bacteremia Bacteremia and Sepsis Bacterial Infections Bacterial Infections and Mycoses Infections Inflammation Intensive Care Medicine Pathologic Processes Pathological Conditions, Signs and Symptoms Procalcitonin Septic Shock Shock, Septic Systemic Inflammatory Response Syndrome

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Gulhane Training and Research Hospital

Ankara, Türkiye, 06010, Turkey (Türkiye)

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Positive blood culture during their follow up
  • Patients over 18 years of age

Exclusion criteria

  • Those under the age of 18
  • Those who have had surgery or trauma in the last 72 hours
  • Those with a history of autoimmune disease, chronic renal failure
  • Patients admitted to intensive care due to acute pancreatitis, pregnancy, burns.
  • Patients with incomplete data.

Treatment and study plan

Primary outcomes

  1. Correlation of serum PCT levels measured within 24 hours of culture in intensive care patients with bacteremia and the pathogen type (Gram-positive, Gram-negative, fungal) in the culture result.

    Time frame: In patients with positive blood cultures, serum PCT values studied within the first 24 hours from the time the culture sample was taken will be evaluated retrospectively.

Secondary outcomes

  1. Diagnostic power of PCT levels in distinguishing Gram-negative, Gram-positive and fungal infections

    Time frame: serum PCT values studied within the first 24 hours from the time the culture sample

Sponsors and collaborators

Lead sponsor

Gulhane Training and Research Hospital

Other Gov

Registry information

Important dates

Study start
2023
Primary completion
2025
Study completion
2025
First posted
May 6, 2025
Registry last updated
Dec 11, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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