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OpenTrials
Completed

NCT Number: NCT03711227

Procalcitonin at Zero and 24 Hours as a Prognostic Factor in Patients With Pneumonia

Procalcitonin levels checked initially and at 24 hours will correlate with disease severity, morbidity, and mortality. Patients who have a higher procalcitonin level initially and at 24 hours will likely have higher qSOFA scores, longer lengths of stay, longer duration of antibiotics and higher 30 day mortality rates.

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Key information

Conditions

Pneumonia Infections Inflammation Lung Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Respiratory Tract Diseases Respiratory Tract Infections Sepsis Systemic Inflammatory Response Syndrome

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Lakeland Regional Healthcare

Saint Joseph, Michigan, 49085, United States

About this study

A procalcitonin order bundle will be created for admitted patients with pneumonia. This prepopulated bundle includes an initial and 24 hour procalcitonin level, much like the current initial and 4 hour lactate orders are set-up. These patients will receive treatment for their pneumonia as is deemed appropriate by their care teams, both in the Emergency Department and while an inpatient. Then, after discharge, the 30 day mortality, length of stay, choice of antibiotic therapy, and qSOFA score (which will be retroactively calculated) will be compared to the patient's initial and 24 hour procalcitonin level.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • All patients seen at Lakeland St. Joseph and Niles Hospitals in the emergency department and who are then subsequently admitted with pneumonia at Lakeland St. Joseph and Niles Hospitals

Exclusion criteria

  • Any patients not admitted with pneumonia, any patients who are admitted with another primary diagnosis other than pneumonia, any patients who do not have an initial or 24 hour procalcitonin level result, and any patients less than 18 years old

Treatment and study plan

Procalcitonin lab test

Diagnostic Test

A procalcitonin order bundle will be created for admitted patients with pneumonia. This prepopulated bundle includes an initial and 24 hour procalcitonin level.

Primary outcomes

  1. Change in Procalcitonin level

    Time frame: Measured at baseline and at 24 hours

    Change in procalcitonin level in the blood serum

Secondary outcomes

  1. qSOFA score

    Time frame: baseline and at 24 hours

    qSOFA score is based on blow blood pressure, high respiratory rate, and altered mental status

  2. Length of stay

    Time frame: an average of 30 days

    Length of stay in days, total stay from admission until discharge

  3. Duration of antibiotics

    Time frame: an average of 30 days

    Antibiotic treatment length in days

  4. 30 Day Mortality

    Time frame: 30 days

    Number of patients who expire vs those alive at 30 days

Sponsors and collaborators

Lead sponsor

Corewell Health South

Other

Collaborators

  • Michigan State University

Registry information

Important dates

Study start
2018
Primary completion
2019
Study completion
2019
First posted
Oct 18, 2018
Registry last updated
Nov 29, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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