Skip to main content
OpenTrials
Completed

NCT Number: NCT02243254

Prevention of Remifentanil-induced Postoperative Hyperalgesia With Intravenous Ibuprofen

Postoperative hyperalgesia has been reported after intraoperative administration of small or high-dose remifentanil. Cyclooxygenase inhibitor exhibit preventive effects on the development of opioid-induced hyperalgesia. The aim of this study is to evaluate the preventive effect of intravenous ibuprofen (Caldolor®) on remifentanil-induced hyperalgesia

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Ibuprofen Hyperalgesia Nervous System Diseases Neurologic Manifestations Pain Pain, Postoperative Pathologic Processes Pathological Conditions, Signs and Symptoms Postoperative Complications Remifentanil Sensation Disorders Signs and Symptoms Somatosensory Disorders

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Seoul National University Hospital

Seoul, South Korea

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adult patients scheduled for elective pancreaticoduodenectomy

Exclusion criteria

  • Patients with chronic pain
  • Patients with psychiatric disease
  • Patients with nonsteroidal antiinflammatory drugs allergy
  • Patients with renail dysfunction
  • History of drug addiction
  • Pregnant patient
  • Inability to use a PCA device

Treatment and study plan

High dose Remifentanil

Drug

high dose remifentanil

Ibuprofen

Drug

intravenous ibuprofen

Low dose remifentanil

Drug

low dose remifentanil

Primary outcomes

  1. cumulative morphine consumption

    Time frame: postoperative 48 hours

    cumulative patient-controlled analgesia (PCA) morphine consumption

Secondary outcomes

  1. Pain score

    Time frame: postoperative 1, 3, 6,12, 24, 48 hours Pain score

    visual analogue scale

Sponsors and collaborators

Lead sponsor

Seoul National University Hospital

Other

Registry information

Important dates

Study start
2014
Primary completion
2015
First posted
Sep 17, 2014
Registry last updated
Nov 18, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.