Dept. of Occupational Medicine, Haukeland University Hospital
Bergen, 5021, Norway
NCT Number: NCT01602237
The study is a follow-up of investigations done in the years 1999-2002 in bakery employees. The main purposes are to look at the associations between flour dust exposure and respiratory disease, and to find out the best ways to reduce the flour dust levels in the working environment.
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Notify Me18 year–80 year
All sexes
Observational
Bergen, 5021, Norway
Background and Methods:
Supported by the The Confederation of Norwegian Enterprise (CNBI) Working Environment Fund a follow-up study of 184 bakery workers in 5 bakeries was done in 2012, appr. 10 years after a similar study in 1999-2002. In addition a cross-sectional study in 2 other bakeries (one 'bread-factory', and a traditional bakery with three small bake shops) was added.
Altogether 253 participants, among them 61 former bakery workers, were investigated with use of questionnaires, allergy-testing (skin prick testing, and blood samples for specific IgE and total IgE), spirometry with reversibility testing, exhaled NO-measurement, and nasal measurements.
As in 1999-2002 an extensive exposure assessment was performed including personal samples of total dust (Gelman), inhalable dust (PAS6), as well as direct reading measurements of dust (Dust Track). A Job Exposure Matrix (JEM) was created enabling each participant to be assigned an exposure value of probable mean daily flour-dust exposure based on work-tasks and bakery.
Aim of study:
Healthy volunteers accepted: No
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
Time frame: Change/decline from 1999-2002 to 2012
The decline in FEV1 from 1999-2002 to 2012.
Time frame: Each participant will be investigated once. Anticipated recruitment time for the whole cohort (study population I and II): about 10 months.
Before and after salbutamol-inhalation. Post-bronchodilatory measurements of FEV1 and FVC to measure the prevalence of chronic obstructive lung disease in a cohort of bakery workers
Time frame: Each participant will be investigated once. Anticipated recruitment time for the whole cohort (study population I and II): about 10 months.
Measurement in nasal lavage of inflammation markers (albumin, tryptase, eosinophilic cationic protein) when at work (field study)
Time frame: Each participant will be investigated once. Anticipated recruitment time for the whole cohort (study population I and II): about 10 months.
In serum measurement of specific IgE to common airborne allergens, and allergens mainly found in bakeries
Time frame: Each participant will be investigated once. Anticipated recruitment time for the whole cohort (study population I and II): about 10 months.
Skin prick test with commercially available allergen extracts (common and occupational allergens in bakeries)
Haukeland University Hospital
Other
Preventing Respiratory Health Problems in Bakery Employees.
Acronym: Baker2012
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View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.
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