Prevalence of Wild Type Transthyretin Cardiac Amyloidosis in Patients Operated for Idiopathic Carpal Tunnel Syndrome

Wild-type transthyretin cardiac amyloidosis is an underdiagnosed depository disease in which fibril monomers of misfolded amyloid protein accumulates in various tissues, including the heart, and cause tissue dysfunction.

Before onset of cardiac symptoms, many patients will have undergone surgery for idiopathic carpal tunnel syndrome since the protein also deposits in the transversal carpal ligament of the hand.

This study investigates patients previously operated for idiopathic carpal tunnel syndrome to determine if they display signs and symptoms of cardiac amyloidosis.

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Key information

Conditions

Amyloidosis Cardiac Amyloid Neuropathies Amyloid Neuropathies, Familial Amyloidosis Amyloidosis, Familial Carpal Tunnel Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities Cumulative Trauma Disorders Genetic Diseases, Inborn Heredodegenerative Disorders, Nervous System Median Neuropathy Metabolic Diseases Metabolism, Inborn Errors Mononeuropathies Nerve Compression Syndromes Nervous System Diseases Neurodegenerative Diseases Neuromuscular Diseases Nutritional and Metabolic Diseases Peripheral Nervous System Diseases Proteostasis Deficiencies Sprains and Strains Wounds and Injuries

Age range

60 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Department of Heart Disease

Aarhus, 8200, Denmark

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients above sixty years of age previously operated for idiopathic carpal tunnel syndrome within the Region of Central Denmark (Region Midtjylland) the last five years.
Informed written and verbal consent

Exclusion criteria

Operation by different indication such as

Fracture
Ganglion
Tumors
Osteophytes
Rheumatoid Arthritis
Persistent medial artery
Metabolic causes
Alcoholism
Hyperthyroidism
Myxedema

Hereditary Cardiac Amyloidosis
Known WT ATTR
AL Amyloidosis
Myelomatosis
MGUS and Morbus Waldenström

Treatment and study plan

DPD Scintigraphy

Diagnostic Test

Confirms/Refutes diagnosis of cardiac amyloidosis.

Primary outcomes

Prevalence of cardiac amyloidosis.

Time frame: Through study completion, an average of 2 years.

The prevalence of cardiac amyloidosis among patients previously operated for ipiopathic carpal tunnel syndrome.

Sponsors and collaborators

Lead sponsor

Aarhus University Hospital Skejby

Other

Collaborators

Regional Hospital Holstebro

Registry information

Acronym: CACTuS

Important dates

Study start: 2019
Primary completion: 2020
Study completion: 2020
First posted: Jun 24, 2019
Registry last updated: Oct 8, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed