Prevalence of Molar Incisor Hypomineralization Among Children Treated With Asthmatic Drugs Early in Their Lives

The aim of this study is to assess the prevalence of molar incisor hypo mineralization among children who have been treated with asthmatic drugs during the first three years of life.

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Key information

Conditions

Molar Incisor Hypomineralization Asthma in Children Congenital Abnormalities Congenital, Hereditary, and Neonatal Diseases and Abnormalities Dental Enamel Hypomineralization Developmental Defects of Enamel Molar Hypomineralization Stomatognathic Diseases Stomatognathic System Abnormalities Tooth Abnormalities Tooth Diseases

Age range

8 year–12 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Agouza police hospital

Giza, Egypt

About this study

The term Molar incisor hypo mineralization (MIH) was first introduced in 2001 as a developmental disorder of enamel characterized by hypo mineralization -of systemic origin - affecting the enamel of first permanent molars (PFM) ,frequently associated with affected permanent incisors.

The prevalence of MIH varies widely, ranging from 2.4 % to 40.2% in different populations. This wide variation may be due to differences in diagnostic criteria and methodologies used by the authors. Concerning the etiology of MIH it is mostly related to pre natal, perinatal, and post natal illness.

Asthma and asthmatic drugs have been proposed to be one of the etiological factors of MIH,Internationally, the mean prevalence of pediatric asthma is 10%.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Children from 8 to 12 years old with fully erupted first permanent molars and permanent incisors.
Children who were patients of the Pediatric Pulmonary Clinic and had used asthma drugs (oral and inhaled bronchodilators or corticosteroids) during their first three years of life.

Exclusion criteria

Children with any chronic disease
Children with unerupted or partially erupted first permanent molars.
Children using a fixed orthodontic appliance
Children having extensive carious lesions that might mask dental enamel defects.

Treatment and study plan

Primary outcomes

Prevalence of molar incisor hypo mineralization (MIH)

Time frame: baseline
- Clinical examination will be carried out by the principle investigator using mirror and probe to examine all surfaces of each first permanent molar &permanent incisors following the diagnostic criteria of MIH set by the European Academy of Pediatric Dentistry (EAPD)as following :Demarcated opacities:
Enamel disintegration:

Atypical restorations:

Extracted teeth:

Tooth sensitivity:

Secondary outcomes

the severity of MIH

Time frame: baseline

the severity of MIH will be recorded into three categories :Mild MIH , Moderate MIH, and Severe MIH

Sponsors and collaborators

Lead sponsor

Cairo University

Other

Registry information

Official study title

Prevalence of Molar Incisor Hypo Mineralization Among Children Who Have Been Treated With Asthmatic Drugs During Their First Three Years of Life(A Cross- Sectional Study)

Important dates

Study start: 2020
Primary completion: 2022
Study completion: 2022
First posted: Sep 25, 2019
Registry last updated: Sep 6, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed