Pressure Dependent Tracheal Obstruction in Copd Patients

Background. Do pressure dependent tracheal obstructions (PDTO) often seen during bronchoscopy in COPD patients affect pulmonary function tests and breathing symptoms? Method. Model study. A garden hose was compressed from one side to simulate the posterior wall of the trachea bulging into the lumen. For two obstruction lengths - 3 cm and 12 cm, the hose was increasingly compressed in eight steps. Resistance was measured at each step for airflows 1 l/s through 9 l/s, and digital photos of the luminal area were taken which were used by a computer to estimate the cross sectional area reduction and the corresponding distance between the bulging (posterior)and the opposite (anterior) wall (AP-distance).

Patient study. 104 stable COPD patients studied by pulmonary function tests and bronchoscopy. The tracheal obstruction was observed during forced expiration and cough, and the cross sectional area reduction was estimated using the results from the model study.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Tracheobronchomalacia Airway Obstruction Bronchial Diseases Cartilage Diseases Chronic Disease Congenital Abnormalities Congenital, Hereditary, and Neonatal Diseases and Abnormalities Connective Tissue Diseases Disease Attributes Lung Diseases Lung Diseases, Obstructive Musculoskeletal Abnormalities Musculoskeletal Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Pulmonary Disease, Chronic Obstructive Respiration Disorders Respiratory Insufficiency Respiratory Tract Diseases Skin and Connective Tissue Diseases Tracheal Diseases

Sex eligibility

All sexes

Study type

Observational

Primary location

Glittreklinikken

Hakadal, Akershus, 1485, Norway

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

copd

Exclusion criteria

clinical evidence of malignant disease
not able to be subjected to bronchoscopy

Sponsors and collaborators

Lead sponsor

LHL Helse

Other

Registry information

Acronym: PDTO

Important dates

Study start: 2004
Primary completion: 2006
Study completion: 2011
First posted: Sep 6, 2012
Registry last updated: Sep 6, 2012

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed