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Completed

NCT Number: NCT06539156

Prescribing Appropriateness of Thrombo-prophylaxis in Intensive Care Unit of Tertiary Hospital

Hospitalized patients are at high risk of venous thromboembolism (VTE), and the appropriate use of thromboprophylaxis can significantly reduce the incidence of VTE in high-risk patients. We investigated the pattern of VTE prophylaxis administration among elderly medical patients and assessed its appropriateness based on the American College of Chest Physicians (ACCP) recommendations. Methods A cross-sectional single-center study will be conducted between July 2024 and December 2024, including hospitalized (> 48 h), (≥ 60 years), medical and surgical patients, and excluding patients receiving anticoagulant for other reason, having contraindication to thromboprophylaxis, or had VTE diagnosed within 48 h. The Padua and caprine prediction scores will be used to determine the patients' risk for VTE, and thromboprophylaxis use will be assessed against the ACCP recommendations.

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Key information

Conditions

DVT

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Teachers Hospital

Cairo, Cairo Governorate, 4270020, Egypt

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patient records

  • admitted to the ICU with
  • medical or surgical causes
  • recieved anticoagulants for DVT prophylaxis

Exclusion criteria

  • Patients already on anticoagulant therapy,
  • had history of previous DVT,
  • had End-stage liver disease,
  • admitted with hemorrhage/bleeding
  • not prescribed DVT prophylaxis

Treatment and study plan

DVT prophyllaxis

Other

VTE prophylaxis administration among patients based on the American College of Chest Physicians (ACCP) recommendations

Primary outcomes

  1. Padua score for medical patients

    Time frame: within 24 hours of ICU admission

    Venous thromboembolism Risk assessment (Scores 0-3 are low risk and do not warrant prophylaxis. Scores ≥4 are high risk for VTE and subsequent complications; recommendation for thromboprophylaxis.)

  2. Caprini score for surgical patients

    Time frame: within 24 hours of ICU admission

    Venous thromboembolism Risk assessment (Total score of 0-1: Low risk of VTE Total score of ≥3: High/moderate risk of VTE )

Secondary outcomes

  1. Bleeding risk assessment

    Time frame: within 24 hours of ICU admission

  2. Direct Anticoagulant cost

    Time frame: within 24 hours of ICU admission till ICU discharge(at least 48 hours)

    sum of costs related to the anticoagulant administration for DVT Prophylaxis

  3. Adverse drug reaction cost

    Time frame: within 24 hours of ICU admission till ICU discharge (at least 48 hours)

    sum of costs related to the Adverse drug reaction for DVT Prophylaxis

Sponsors and collaborators

Lead sponsor

Ain Shams University

Other

Collaborators

  • Egyptian Chinese University
  • Teachers Hospital

Registry information

Official study title

Pattern of Prescribing Anticoagulants As DVT Prophylaxis in Intensive Care Unit of Tertiary Hospital

Important dates

Study start
2024
Primary completion
2024
Study completion
2024
First posted
Aug 6, 2024
Registry last updated
Dec 27, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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