Preopioid Versus Nonopioid in Total Knee Arthroplasty (TKA)

Observational study evaluating pain response after total knee arthroplasty (TKA) in patients taking strong, weak or no opioids preoperatively.

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Key information

Conditions

Postoperative Pain Neurologic Manifestations Pain Pain, Postoperative Pathologic Processes Pathological Conditions, Signs and Symptoms Postoperative Complications Signs and Symptoms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Dep. of ortopedic surgery, Gentofte Hospital, Hellerup, Denmark

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients operated with elective, primary, unilateral total knee arthroplasty (TKA) (taking strong or weak opioid daily for minimum 4 weeks or opioid naive patients)

Exclusion criteria

Bilateral / revision arthroplasty
Disease affection central or peripheral nerve function
Alcohol and medical abuse
Daily use of glucocorticoids
Malignancy
BMI > 40
Dementia or other cognitive dysfunction
Treatment of anxiety or depression

Treatment and study plan

Primary outcomes

Pain

Time frame: 24 hours

Pain during ambulation and at rest

Secondary outcomes

Pain

Time frame: 7 days

Pain during ambulation and at rest
Opioid consumption

Time frame: 7 days

Sponsors and collaborators

Lead sponsor

Hvidovre University Hospital

Other

Registry information

Official study title

Acute Pain After Fast-track Total Knee Arthroplasty: Preoperative Opioid Versus Non-opioid

Important dates

Study start: 2011
Primary completion: 2013
Study completion: 2013
First posted: Mar 25, 2011
Registry last updated: Jun 5, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed