Preoperative Neutrophil-to-Lymphocyte Ratio and Early Postoperative Pain After Septorhinoplasty

This prospective, observational study investigates the relationship between early oxygen exposure and oxidative stress in adult intensive care unit patients with sepsis or septic shock. Fraction of inspired oxygen (FiO₂) administered during the first 24 hours of ICU admission will be recorded and analyzed in relation to changes in the uric acid/albumin ratio (UAR), a biomarker reflecting oxidative burden and inflammation. Serum uric acid and albumin levels will be measured at baseline and at 24 hours, and the percentage change in UAR will be calculated. Secondary analyses will examine associations between UAR changes, oxygenation indices, and 28-day mortality. The study aims to determine whether higher FiO₂ exposure is associated with increased oxidative stress and to evaluate the potential role of UAR as a clinically accessible marker of oxygen-related oxidative injury in septic ICU patients.

Not Yet Recruiting

Trial opening soon.

Get Notified

Key information

Conditions

Neutrophil-to-Lymphocyte Ratio Septorhinoplasty

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Observational

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Adult patients aged 18-65 years
Patients undergoing elective septorhinoplasty
Surgery performed under general anesthesia
Complete recording of early postoperative VAS pain scores, Aldrete scores, NUDES scores, and vital signs in the Post-Anesthesia Care Unit (PACU)
Preoperative complete blood count (hemogram) performed within 30 days prior to surgery
Clinical records and hospital information system data that are complete, accessible, and adequate for analysis

Exclusion criteria

Patients undergoing emergency surgery
Septorhinoplasty combined with additional major surgical procedures (e.g., advanced ENT or maxillofacial surgery)
Presence of known hematological disease, active infection, immunosuppressive therapy, or advanced liver or renal failure
Chronic opioid use or regular analgesic medication use in the preoperative period
History of significant clinical events between the preoperative hemogram and surgery that could alter inflammatory status (e.g., infection, hospitalization, additional surgery)
Incomplete or missing data regarding preoperative hemogram parameters or PACU pain scores

Treatment and study plan

observational study

Other

Not applicable. This is a prospective observational study. No intervention or alteration to standard treatment protocols will be performed. Clinical and laboratory data obtained during routine care, including preoperative hemogram parameters and early postoperative pain scores, will be recorded and analyzed without influencing patient management.

Primary outcomes

Early Postoperative Pain Severity

Time frame: Within the first 60 minutes after admission to the Post-Anesthesia Care Unit (PACU).

early postoperative pain severity, as measured using the Visual Analog Scale (VAS). 0: no pain, 10 worst pain

Study contacts

Contact information is provided by the study sponsor or research team.

İLKE DOLĞUN

CONTACT

[email protected]

+905555485632

Sponsors and collaborators

Lead sponsor

Istinye University

Other

Registry information

Official study title

The Relationship Between Preoperative Neutrophil-to-Lymphocyte Ratio and Hemogram Parameters and Early Postoperative Pain Scores in Patients Undergoing Septorhinoplasty

Important dates

Study start: 2026
Primary completion: 2026
Study completion: 2026
First posted: Jan 20, 2026
Registry last updated: Jan 20, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed