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Completed

NCT Number: NCT07064642

NLR and Sevoflurane Use in Ear Surgeries: Flow Comparison

This retrospective study aims to compare the effects of low-flow and high-flow anesthesia techniques on intraoperative hemodynamics, neutrophil-to-lymphocyte ratio (NLR), and postoperative outcomes in patients undergoing tympanoplasty or myringoplasty. The data were collected from medical records of patients who underwent ear surgery between [September 1, 2022] and [April 1, 2023]. The study seeks to evaluate whether the choice of anesthetic flow rate has a significant impact on inflammatory response and recovery.

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Key information

Conditions

Tympanoplasty High-flow Anesthesia Low-flow Anesthesia Myringoplasty Neutrophil-to-Lymphocyte Ratio

Age range

18 year–75 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Karadeniz Technical University Faculty of Medicine Hospital

Trabzon, 61080, Turkey (Türkiye)

About this study

This study investigates the influence of anesthetic gas flow rates on systemic inflammation and hemodynamic stability in middle ear surgeries. While low-flow anesthesia is associated with reduced environmental exposure and cost-effectiveness, its impact on inflammatory markers and recovery outcomes remains less clearly defined. The neutrophil-to-lymphocyte ratio (NLR) is used as a readily available, cost-effective biomarker of systemic inflammation. This study retrospectively analyzes perioperative data from patients who underwent tympanoplasty or myringoplasty, comparing NLR levels, intraoperative vital signs, and postoperative recovery parameters between low-flow and high-flow anesthesia groups. The results may contribute to optimizing anesthetic strategies in otologic surgeries, with emphasis on inflammation modulation and patient safety.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adults aged between 18 and 75 years
  • American Society of Anesthesiologists (ASA) physical status classification I to III
  • Body Mass Index (BMI) between 18.5 and 29.9 kg/m²

Exclusion criteria

  • Age below 18 or above 75 years
  • Incomplete or missing clinical data
  • BMI less than 18.5 kg/m² or greater than 29.9 kg/m²
  • Presence of neurological disorders
  • History of renal or hepatic failure

Treatment and study plan

Primary outcomes

  1. Postoperative neutrophil-to-lymphocyte ratio (NLR)

    Time frame: Within 1 hour postoperatively (Day 0)

    The neutrophil-to-lymphocyte ratio measured from blood samples taken immediately after surgery to assess the systemic inflammatory response in patients undergoing tympanoplasty or myringoplasty with low-flow or high-flow anesthesia.

Sponsors and collaborators

Lead sponsor

Eda KAZANÇ ÖZDEN

Other

Registry information

Official study title

A Retrospective Comparison Of The Effects Of Low-Flow And High-Flow Anesthesia On Hemodynamics, Neutrophil-To-Lymphocyte Ratio, And Postoperative Outcomes In Tympanoplasty And Myringoplasty Surgeries

Acronym: ANFLUX

Important dates

Study start
2023
Primary completion
2023
Study completion
2023
First posted
Jul 15, 2025
Registry last updated
Jul 17, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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