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OpenTrials
Completed

NCT Number: NCT01280253

Preoperative Biochemical Predictors of Outcome in Patients With Hip Fracture

The objective of the study is to identify biochemical predictors of morbidity and mortality in patients suffering from hip fracture. For this purpose blood samples are collected prehospitally or in the emergency department in patients with a suspected hip fracture. During the hospital stay medical history, anesthesiological management recorded. In addition, american society of anesthesiology physiological score (ASA), revised cardiac risk index (RCRI), and POSSUM score is calculated. Morbidity and mortality is recorded " in house", after 30 days, after 4 months and after 1 year. Biochemical predictors of outcome will be evaluated with logistic regression analysis. Biochemical predictors include pro-brain natriuretic peptide, lactate, pro-calcitonin, adrenomedullin, copeptin, cystatin c. The predictive value of the potential markers will be compared to that of ASA, RCRI and POSSUM.

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Key information

Conditions

Hip Fracture Femoral Fractures Fractures, Bone Hip Fractures Hip Injuries Leg Injuries Wounds and Injuries

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Skane University Hospital, Lund

Lund, Skåne County, 22285, Sweden

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients presenting with out of hospital hip fracture at University Hospital Lund Sweden
  • Informed consent
  • Blood sampling within 3 hrs of first contact with healthcare

Exclusion criteria

  • No consent can be obtained
  • Non-operative management
  • Followup through the Swedish National Quality for Hip fracture patients not possible
  • High energy trauma

Treatment and study plan

Primary outcomes

  1. Mortality

    Time frame: 30 days

Secondary outcomes

  1. Morbidity

    Time frame: 30 day

    Infectious complications Cardiovascular complications Thromboembolic complications Respiratory complications Renal complications Surgical complications

Sponsors and collaborators

Lead sponsor

Region Skane

Other

Collaborators

  • Anna and Edwin Berger Foundation

Registry information

Official study title

Can Biochemical Tests Predict Outcome in Patients With Hip Fracture?

Important dates

Study start
2011
Primary completion
2014
First posted
Jan 20, 2011
Registry last updated
Nov 15, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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