Prenatal and Postnatal Ultrasonographic Evaluation of Myelomeningocele to Predict Post-Surgical Outcomes

Myelomeningocele (MMC), also known as open spina bifida, is a serious congenital condition in which the cord and meninges protrude through the spinal column's defective bony encasement due to a defective closure of the posterior portion of the neural tube between the fourth week of pregnancy.

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Key information

Conditions

Myelomeningocele Congenital Abnormalities Congenital, Hereditary, and Neonatal Diseases and Abnormalities Meningomyelocele Nervous System Diseases Nervous System Malformations Neural Tube Defects

Age range

28 week–40 week

Sex eligibility

All sexes

Study type

Observational

Primary location

Allied Hospital

Faisalābad, Punjab Province, Pakistan

About this study

The formation of the defect is influenced by both genetic and environmental factors, while the exact cause is yet unknown. There is currently no effective treatment for this common and debilitating central nervous system (CNS) dysfunction.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Gestational age 3rd trimester, Lesion between T1 and S1, Hindbrain herniation and Normal karyotype

Exclusion criteria

Multiple gestation pregnancy
Other fetal anomalies unrelated to myelomeningocele
History of incompetent cervix, Other serious maternal medical conditions
Inability to adhere to travel and follow-up requirements
Contraindication to surgery and Inability to meet trial psychosocial criteria.

Treatment and study plan

G.E HEALTHCARE ultrasound machine with high-resolution convex probe

Diagnostic Test

After approval from the institutional ethical committee, a total number of patients presenting to the Radiology and Peads Neurosurgery department of Allied Hospital, Faisalabad, that met the inclusion criteria was selected. After obtaining informed consent from each patient and attendant of the patient, transabdominal ultrasound was examined longitudinal, transverse and oblique plans, ultrasound with a high- resolution convex probe was used by the radiologist

Primary outcomes

self administered questioner

Time frame: 12 Months

self administered questioner for yelomeningocele patients scroing range fron 0-40. 0 is for lower and 40 is worse and higher

Sponsors and collaborators

Lead sponsor

Superior University

Other

Registry information

Important dates

Study start: 2025
Primary completion: 2025
Study completion: 2026
First posted: Jul 2, 2025
Registry last updated: Jul 2, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

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This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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