Pregnane X Receptor (PXR) Agonist Rifampicin Effects on Glucose, Lipid and Hormone Homeostasis

This clinical trial is designed to study the effects of rifampicin on the glucose, lipid and hormone homeostasis in healthy volunteers. The main hypothesis is that rifampicin lowers fasting glucose and enhances insulin sensitivity. The study is a randomized, placebo-controlled, open-label cross-over trial. Twelve subjects will be given 600 mg of rifampicin a day for a week compared to a one-week placebo arm. There is at least a 4-week wash-out between the arms. The main outcome measures are the changes in the fasting glucose and HOMA-IR-index (calculated based on fasting glucose and insulin).

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Key information

Conditions

Glucose Tolerance

Age range

18 year–40 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

Oulu University Hospital

Oulu, 90220, Finland

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Healthy volunteer
Age 18-40 years

Exclusion criteria

Any continuous medication
Any significant disease
Allergy to rifampicin
Pregnancy and breast feeding
Fear of needles and previous difficult blood samplings
Substance abuse
Participation in another clinical drug trial within 1 month of enrollment
Use of soft contact lenses

Treatment and study plan

rifampicin

Drug

Other names: Rimapen, ATC J04AB02

Placebo

Drug

Primary outcomes

Fasting glucose

Sponsors and collaborators

Lead sponsor

University of Oulu

Other

Registry information

Official study title

PXR-agonisti Rifampisiinin Vaikutukset Glukoosi-, Lipidi- ja Hormonihomeostaasiin

Important dates

Study start: 2009
Primary completion: 2010
Study completion: 2010
First posted: Sep 28, 2009
Registry last updated: Feb 10, 2011

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed