Predictors of Treatment Outcome for Smokers With and Without Schizophrenia

The primary purpose of this investigation is to determine the predictive value of task persistence as measured by a mirror tracing task. A secondary purpose is to evaluate differences in task persistence in smokers with or without schizophrenia. It is hypothesized that task persistence in smokers in both diagnostic categories (schizophrenia and no schizophrenia) will predict tobacco dependence treatment outcome at one and six months. It is also hypothesized that smokers with schizophrenia will show lower levels of task persistence after controlling for other motor skills than smokers without schizophrenia.

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Key information

Conditions

Tobacco Dependence Chemically-Induced Disorders Mental Disorders Substance-Related Disorders Tobacco Use Disorder

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

UMDNJ Tobacco Dependence Clinic

New Brunswick, New Jersey, 08901, United States

About this study

Please see brief summary above.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Current smokers must be over the age of 18,
Must fit into the diagnostic groups schizophrenia / schizoaffective disorder; or the non-schizophrenia group.
Must smoke at least 10 cigarettes per day
Must be capable of giving informed consent as measured by Folstein Mini Mental Status Exam of at least 22.

Exclusion criteria

Those unable to give informed consent.
Psychotic disorders other than schizophrenia

Treatment and study plan

Primary outcomes

Mirror-tracing Persistence (in Seconds)

Time frame: baseline

Number of seconds participants continued working on a mirror tracing task before giving up.

Secondary outcomes

Persistence as a Prospective Predictor of Smoking Cessation

Time frame: 6 months

Analysis of Generalized Estimating Equations (GEE) parameter estimates based on empirical standard error estimates, using an exchangeable working correlation structure, with smoking abstinence as outcome variable, and task persistence, time, diagnosis, ability, Fagerstrom Test for Nicotine Dependence (FTND) score, and the interaction between disorder and persistence as explanatory variables.

Sponsors and collaborators

Lead sponsor

Rutgers, The State University of New Jersey

Other

Collaborators

National Institute on Drug Abuse (NIDA)

Registry information

Important dates

Study start: 2005
Primary completion: 2012
Study completion: 2013
First posted: Jul 13, 2007
Registry last updated: Jul 17, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed