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NCT Number: NCT07279519

Predictive Value of Frailty Scores and Admission Laboratory Markers for Postoperative ICU Mortality

This prospective observational study aims to evaluate the predictive value of the Clinical Frailty Scale (CFS), the Katz Activities of Daily Living (ADL) scale, and admission laboratory markers for postoperative mortality among geriatric patients admitted to the intensive care unit (ICU) after surgery. Frailty assessment and functional status are increasingly recognized as determinants of outcomes in older adults, yet their combined predictive power with routine laboratory parameters at ICU admission remains unclear. By systematically collecting clinical scores and laboratory data at the time of ICU admission, this study seeks to identify early predictors of mortality and support risk-stratification in geriatric postoperative patients.

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Key information

Conditions

Postoperative Mortality Activities of Daily Living Frailty Frailty At Older Adults Pathologic Processes Pathological Conditions, Signs and Symptoms Postoperative Complications

Age range

65 year–65 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Malatya Eğitim Araştırma Hastanesi

Malatya, 44000, Turkey (Türkiye)

About this study

This prospective observational study aims to evaluate the predictive value of the Clinical Frailty Scale (CFS), Katz Activities of Daily Living (ADL) score, and admission laboratory markers for postoperative ICU mortality in geriatric patients. Frailty and functional dependency are known to influence postoperative outcomes; however, their combined role alongside early biochemical indicators at the time of ICU admission has not been well defined in this population.

In this study, patients aged 65 years and older who are admitted to the intensive care unit following surgery will be assessed using the CFS and Katz ADL scores within the first hours of ICU admission. Laboratory data obtained at the time of admission-including complete blood count, renal and hepatic panels, electrolytes, markers of inflammation, and arterial blood gas parameters-will be recorded. Patients will subsequently be followed throughout their ICU stay to document clinical course and outcomes, with ICU mortality designated as the primary endpoint.

The goal of this research is to identify which frailty indicators and laboratory markers are independently associated with mortality, and to explore whether combining functional status scores with early laboratory abnormalities improves risk stratification in geriatric postoperative ICU patients. The findings may support the development of simple, bedside-applicable tools for early mortality prediction and clinical decision-making in this high-risk population.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Individuals aged 65 years and older Undergoing elective or emergency surgery Monitored in the intensive care unit for at least 24 hours after surgery Provision of informed consent by the patient or the legal representative

Exclusion criteria

Patients with incomplete or unavailable data sets ICU stays shorter than 24 hours Patients admitted for organ transplantation or those in the terminal stage receiving palliative care

Treatment and study plan

Primary outcomes

  1. 30-day ICU Mortality

    Time frame: 30 days after ICU admission

    Mortality status will be determined at the time of ICU discharge. Mortality is defined as all-cause death occurring during the postoperative ICU stay. Data will be collected prospectively from the electronic medical record and verified by the ICU clinical team. The outcome will be recorded as a binary variable (survived / died)

Secondary outcomes

  1. Rate of ICU Length of Stay in Geriatric Postoperative Patients

    Time frame: From ICU admission to ICU discharge (up to 28 days)

    Duration of stay in the intensive care unit, recorded in days. Longer ICU stay is often associated with increased frailty, limited functional capacity, and higher physiological burden. This variable will be extracted from the clinical records and analyzed in relation to frailty, Katz ADL score, and admission laboratory markers.

  2. Association Between Laboratory Markers and Frailty Scores

    Time frame: At ICU admission

    Correlation analysis between baseline laboratory parameters (e.g., hemoglobin, creatinine, CRP, albumin) and frailty assessments (Clinical Frailty Scale and Katz ADL).

Sponsors and collaborators

Lead sponsor

Malatya Egitim Ve Arastirma Hastanesi

Other Gov

Registry information

Official study title

Predictive Value of the Clinical Frailty Scale, Katz ADL, and Admission Laboratory Markers for Postoperative ICU Mortality in Geriatric Patients: A Prospective Observational Study

Acronym: GERI-MORTAL

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Dec 12, 2025
Registry last updated
Jun 1, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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