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NCT Number: NCT07524504

Predictive Role of the Full-mouth Plaque Score on the Outcomes of Non-surgical Periodontal Therapy.

Oral hygiene quality is a key determinant of outcomes in both non-surgical and surgical periodontal therapy. Previous studies have demonstrated the negative impact of site-specific plaque accumulation on periodontal parameters. However, to the best of our knowledge, no studies have specifically investigated the correlation between plaque index and the percentage reduction in periodontal pocket depth, nor its association with other periodontal clinical parameters.

The aim of this study is to evaluate the relationship between plaque index and the percentage reduction in periodontal pockets, as well as its association with key periodontal parameters.

Following baseline data collection, patients will undergo non-surgical periodontal therapy in accordance with current guidelines. Clinical outcomes will be reassessed at 3, 6, 9, and 12 months post-treatment.

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Key information

Conditions

Periodontitis Mouth Diseases Periodontal Diseases Stomatognathic Diseases

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Diagnosis of periodontitis according to current guidelines.
  • Age between 18 and 80 years.

Exclusion criteria

  • Patients who have previously received periodontal treatment.
  • Patients currently on antibiotic therapy or who have taken antibiotics in the past 3 months.
  • Pregnant or breastfeeding women.
  • Presence of systemic diseases or use of medications in which periodontal treatment is contraindicated or could affect study outcomes (e.g., antihypertensives, antiepileptics, immunosuppressants).

Treatment and study plan

Non-surgical periodontal therapy (NSPT)

Procedure

Patients will receive non-surgical periodontal therapy, including professional supragingival (Step 1) and subgingival scaling and root planing (Step 2), according to current guidelines (Herrera et al., 2023). Oral hygiene instructions will be provided at baseline and reinforced at each follow-up visit. Clinical outcomes, including percentage of pocket depth reduction and plaque index (FMPS), will be recorded at 3, 6, 9, and 12 months post-treatment.

Primary outcomes

  1. Percentage of probing pocket depth reduction

    Time frame: Baseline, 3, 6 9 and 12 months

    The primary outcome is the percentage reduction in probing pocket depth (PPD) at treated sites compared to baseline. PPD will be measured using a calibrated periodontal probe at each follow-up visit (3, 6, 9, and 12 months).

Study contacts

Contact information is provided by the study sponsor or research team.

Matteo Serroni, DDS

CONTACT

[email protected]

+393395824161

Matteo Serroni, DDS

CONTACT

Sponsors and collaborators

Lead sponsor

G. d'Annunzio University

Other

Registry information

Official study title

Predictive Role of Full-Mouth Plaque Score on the Outcomes of Non-Surgical Periodontal Therapy: A Prospective Cohort Study

Important dates

Study start
2026
Primary completion
2027
Study completion
2027
First posted
Apr 13, 2026
Registry last updated
Apr 13, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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