Predictive Factors of Graft Detachment Following Dmek

The aim of this study was to identify the predictive factors of graft detachment after Descemet Membrane Endothelial Keratoplasty (DMEK) surgery. This retrospective study was conducted on patients aged 18 years, with Fuchs' dystrophy (FECD) or pseudophakic bullous keratopathy (PBK), who were scheduled for DMEK or triple-DMEK (combined phacoemulsification and DMEK surgery). Patients with a history of surgery other than cataract surgery were excluded. The study was conducted between 2014 and 2022 and follow-up was for 3 months. The characteristics of patients with and without graft detachment following surgery were compared using logistic regression.

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Key information

Conditions

Fuchs' Endothelial Corneal Dystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities Corneal Diseases Corneal Dystrophies, Hereditary Descemet Membrane Endothelial Keratoplasty Eye Diseases Eye Diseases, Hereditary Fuchs' Endothelial Dystrophy Genetic Diseases, Inborn Graft Detachment Pseudophakic Bullous Keratopathy

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

CHR Metz-Thionville/Hopital de Mercy

Metz, 57085, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients over 18 years of age with DMEK surgery

Exclusion criteria

all associated eye surgery other than cataract surgery
all existing anterior segment anomalies

Treatment and study plan

Descemet Membrane Endothelial Keratoplasty

Procedure

DMEK-operated eyes

Primary outcomes

Appearence of the graft on anterior segment optical coherence tomography (AS OCT) examination

Time frame: up to 3 months after surgery

clinical examination and anterior segment optical coherence tomography (AS OCT) examination (appearence of the graft)

Sponsors and collaborators

Lead sponsor

Centre Hospitalier Régional Metz-Thionville

Other

Registry information

Official study title

Predictive Factors of Graft Detachment Following Dmek: Retrospective Study About 170 Cases

Acronym: PDF DMEKDETACH

Important dates

Study start: 2022
Primary completion: 2022
Study completion: 2022
First posted: Sep 8, 2022
Registry last updated: Sep 8, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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