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NCT Number: NCT04452266

Predictive Factor Study of the Occurrence of Endometrial Cancer in Patients With Lynch Syndrome

Lynch Syndrome increases Endometrial Cancer Occurrence in women due to failure in MisMatch Repair System. Lifetime Cumulative risk of developing endometrial Cancer is approximatively 40% in women with Lynch Syndrome.

Endometrial cancer is the third women cancer in France. Many risk factors are known in general population. Lots of factors are related to over exposure to estrogen.

Data about influence of general risk factors in Women with Lynch Syndrome are poor. Recently, a cohort study appears to have shown a significant decrease in the risk of endometrial cancer with multiparity, the use of hormonal contraception and late menopause in Lynch women. The impact of weight and certain metabolic parameters on the occurrence of endometrial cancers remains poorly known to this day.

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Key information

Conditions

Lynch Syndrome Colonic Diseases Colorectal Neoplasms Colorectal Neoplasms, Hereditary Nonpolyposis Congenital, Hereditary, and Neonatal Diseases and Abnormalities DNA Repair-Deficiency Disorders Digestive System Diseases Digestive System Neoplasms Endometrial Neoplasms Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Gastrointestinal Diseases Gastrointestinal Neoplasms Genetic Diseases, Inborn Genital Diseases Genital Diseases, Female Genital Neoplasms, Female Intestinal Diseases Intestinal Neoplasms Metabolic Diseases Neoplasms Neoplasms by Site Neoplastic Syndromes, Hereditary Nutritional and Metabolic Diseases Urogenital Diseases Urogenital Neoplasms Uterine Diseases Uterine Neoplasms

Age range

30 year and older

Sex eligibility

Female

Study type

Observational

Primary location

Hôpital Jeanne de Flandres

Lille, 59000, France

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Lynch Syndrome Diagnosis at University Hospital
  • Alive at study time
  • Age over 30 at endometrial cancer or Lynch Syndrome Diagnosis

Case group :

  • No cancer before endometrial cancer diagnosis

Control group :

  • No endometrial cancer developped
  • Free cancer women at Lynch Syndrome diagnosis

Exclusion criteria

  • Refusing to participate
  • Poor understanding of the French language
  • Other cancer diagnosed before endometrial cancer
  • Hysterectomy before lynch diagnosis for free cancer women

Treatment and study plan

questionnaire assesment

Other

Each patient will to answer questions about their medical history.

Primary outcomes

  1. Correlation between endometrial cancer and predictif factors

    Time frame: Baseline

    Endometrial cancer (yes/no) and explicative variable: Diabetes before endometrial cancer or Lynch syndrome diagnosis; Smoking ; Maximal Weight ; Age at menarche; Parity ; Age at first birth ; Contraceptive use.

Secondary outcomes

  1. Correlation between endometrial cancer and predictif factors in post menopausal woman

    Time frame: Baseline

    Endometrial cancer (yes/no) and explicative variable: Menopause age; Hormonal menopause treatment

Sponsors and collaborators

Lead sponsor

University Hospital, Lille

Other

Registry information

Official study title

Predictive Factor Study of the Occurrence of Endometrial Cancer in Patients With Lynch Syndrome: Study Conducted in the Hauts-de-France

Acronym: PrediLynch

Important dates

Study start
2020
Primary completion
2020
Study completion
2020
First posted
Jun 30, 2020
Registry last updated
Mar 9, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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