Prediction of REsponse to Depression Interventions (Accelerated rTMS) Using Clinical and TD-fNIRS Measurements

Inclusion criteria

for:

Accelerated TMS cohort

• Adults aged 18-75 at the time of enrollment
• Primary diagnosis of MDD as defined by the DSM-5
• Determined by the clinic to be eligible for accelerated rTMS treatment and agrees to receive accelerated rTMS treatment
• Agrees to start accelerated rTMS treatment in conjunction with study participation to capture baseline measurements
• Has not received rTMS treatment in the past 1 month
• Has not received SPRAVATO treatment in the past 1 month
• Can speak and understand English
• Ability to provide informed consent

Healthy controls cohort

• Adults aged 18-75 at time of enrollment
• Can speak and understand English
• Ability to provide informed consent

Exclusion criteria

for:

All cohorts

• Pregnant or may become pregnant during the treatment course
• Unable or unwilling to wear the fNIRS headset
• Has had electroconvulsive therapy (ECT) in the past 3 months
• Major medical illnesses including neurological and psychiatric conditions such as Alzheimer's disease, Parkinson's disease, multiple sclerosis, epilepsy, schizophrenia, or stroke.
• Any other clinically significant medical condition that in the opinion of the clinician or study team, could affect patient safety, wellbeing, or the participant's ability to comply with study procedures.
• Not an appropriate candidate for the study based on the discretion of the study investigator(s).

Healthy controls cohort only

• Clinical diagnosis of depression in the past year
• Undergoing any treatments for depression in the past year