Prediction of Outcome in Severe Preeclampsia

this summary studied the predictive values of factor V Leiden mutation , doppler indices , placental pathology to unfavorable fetal and maternal outcomes

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Key information

Conditions

Leiden Factor V Deficiency,Preeclampsia Doppler Examination Female Urogenital Diseases and Pregnancy Complications Hypertension, Pregnancy-Induced Palental Pathology Pre-Eclampsia Pregnancy Complications Urogenital Diseases

Sex eligibility

Female

Study type

Observational

About this study

leiden mutation is activated protein C resistance with hypercoagulable states and increased thrombotic risk. 99 % are heterozygous and 1 % is homozygous , very rare cases are psoudohomozygous with factor V deficiency. relation to this mutation was studied in severe preeclamptic patients. doppler indices of uterine arteries , increased pulsetility index or unilateral or bilateral uterine artery notch and placental pathology were studied.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

severe preeclampsia in 3rd trimester -

Exclusion criteria

Twin pregnancy. Fetal congenital anomalies. Diabetic patient, impaired renal function. Any medical disorders even that HTN. Any placental pathology,Autoimmune diseases. Women with uterine activity or clinical emergencies with maternal hemodynamic instability or an indication for immediate termination of pregnancy.

Treatment and study plan

blood sample , doppler of uterine vessel and placenta

Diagnostic Test

blood sample for factor V and doppler examination of uterine arteries , placenta pathology post partum

Primary outcomes

percentage of patients develop abruption placenta, intrauterine growth retardation or delivered premature

Time frame: within 12 wks from diagnosis of severe preeclampsia

placental abruption, prematurity, IUGR
percentage of fetuses and neonates complicated with intrauterine fetal death or need admission to incubator

Time frame: from diagnosis of severe preeclampsia till one week after delivery

IUFD, admission to neonatal IUC

Sponsors and collaborators

Lead sponsor

Cairo University

Other

Registry information

Official study title

Relation of 3rd Trimester Uterine Artery Doppler Flow Velocimetry Indices, Factor V Leiden Mutation and Placental Pathology to the Severity of Preeclampsia

Important dates

Study start: 2015
Primary completion: 2016
Study completion: 2017
First posted: Mar 12, 2019
Registry last updated: Mar 12, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed