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Completed

NCT Number: NCT05561621

Prediction of Non-motor Symptoms in Fully Ambulatory MS Patients Using Vocal Biomarkers

The investigator will set up a study evaluating vocal biomarkers in people with MS in order to identify persons with non-motor symptoms: depression, cognitive deterioration, and fatigue. Up to now, to the best of the investigator's knowledge, there is no study reporting the use of vocal biomarkers to predict these three non-motor symptoms in people with MS.

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Key information

Conditions

Multiple Sclerosis Autoimmune Diseases Autoimmune Diseases of the Nervous System Behavior Behavioral Symptoms Demyelinating Autoimmune Diseases, CNS Demyelinating Diseases Depression Fatigue Immune System Diseases Nervous System Diseases Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

18 year–60 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Inselspital University Hospital Bern

Bern, 3010, Switzerland

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Relapsing MS
  • Age over 18
  • EDSS < 4.0
  • Capability of written informed consent

Exclusion criteria

  • Not fluent in german language
  • Relapse or Steroids per os/intra venous < 4 weeks prior to examination
  • KM enhancing lesion in MRI < 4 weeks prior to examination
  • Other previous disease affecting the speech
  • Pregnant patients
  • Mental disability and not able to understand the protocol and study tasks in german languagePatients with greater physical and cognitive disability or history of major depressive disorder and suicide attempt/suicidal thoughts
  • Patients with sleep disorders and comorbidities associated with extreme fatigue (e.g., fibromyalgia)

Treatment and study plan

Voice analysis

Other

Voice analysis

Primary outcomes

  1. Identification of a voice signature that separates between pwMS with and without fatigue

    Time frame: One year

Secondary outcomes

  1. Identification of a voice signature that separates between pwMS with and without cognitive impairment

    Time frame: One year

  2. Identification of a voice signature that separates between pwMS with and without depression

    Time frame: One year

Sponsors and collaborators

Lead sponsor

Insel Gruppe AG, University Hospital Bern

Other

Collaborators

  • Audeering GMBH
  • Biogen

Registry information

Acronym: COMMITMENT

Important dates

Study start
2022
Primary completion
2022
Study completion
2022
First posted
Sep 30, 2022
Registry last updated
Jun 15, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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