Preclinical Study Towards an Immunotherapy in Adrenocortical Carcinoma

Adrenocortical carcinoma (ACC) is a rare and heterogeneous malignancy with poor prognosis. Surgical resection of the tumor is the treatment of choice. However, even after complete resection more than 80 % of patients will experience recurrence of disease. Therefore, new treatment options are urgently needed. This pre-clinical study try to lay the foundations for a successful immunotherapy in patients with ACC.

Active, Not Recruiting

This study is active but is not currently recruiting participants.

Key information

Conditions

Adrenocortical Carcinoma Adenocarcinoma Adrenal Cortex Diseases Adrenal Cortex Neoplasms Adrenal Gland Diseases Adrenal Gland Neoplasms Adrenocortical Hyperfunction Carcinoma Cushing Syndrome Cushing's Syndrome Endocrine Gland Neoplasms Endocrine System Diseases Neoplasms Neoplasms by Histologic Type Neoplasms by Site Neoplasms, Glandular and Epithelial

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Dept. of Medicine I, University of Wuerzburg

Würzburg, 97080, Germany

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

patients with histological proven adrenocortical carcinoma
healthy persons as control group
Life expectancy > 6 months

Exclusion criteria

autoimmune diseases
severe clinical condition

Treatment and study plan

Primary outcomes

To find reasonable antigens for a vaccination therapy in ACC

Time frame: day of blood sampling
To investigate the role of tumor-induced suppression in ACC

Time frame: NA, in vitro study

Sponsors and collaborators

Lead sponsor

University of Wuerzburg

Other

Collaborators

Deutsche Krebshilfe e.V., Bonn (Germany)

Registry information

Official study title

Präklinische Studie Zur Etablierung Einer Immuntherapie für Das Nebennierenrindenkarzinom - Preclinical Study Towards an Immunotherapy in Adrenocortical Carcinoma

Important dates

Study start: 2005
Primary completion: 2029
Study completion: 2030
First posted: Apr 6, 2007
Registry last updated: May 7, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Recruiting