A Prospective Cohort Study for Patients With Adrenal Diseases

The purpose of this study is to investigate the pathologic features, complications, and prognostic factors of functioning adrenal adenoma and suggest follow-up algorithms for adrenal incidentaloma.

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Key information

Conditions

Adrenal Adenoma ACTH Syndrome, Ectopic Adenocarcinoma Adrenal Cortex Diseases Adrenal Cortex Neoplasms Adrenal Gland Diseases Adrenal Gland Neoplasms Adrenal Incidentaloma Adrenocortical Carcinoma Adrenocortical Hyperfunction Carcinoma Cushing Syndrome Endocrine Gland Neoplasms Endocrine System Diseases Hyperaldosteronism Neoplasms Neoplasms by Histologic Type Neoplasms by Site Neoplasms, Germ Cell and Embryonal Neoplasms, Glandular and Epithelial Neoplasms, Nerve Tissue Neuroectodermal Tumors Neuroendocrine Tumors Paraganglioma Paraneoplastic Endocrine Syndromes Paraneoplastic Syndromes Pheochromocytoma Primary Hyperaldosteronism

Age range

19 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Seoul National University Hospital

Seoul, 03080, South Korea

About this study

The investigators will recruit 150 patients annually for 10 years (adrenal incidentaloma 100 patients, pheochromocytoma 15 patients, primary aldosteronism 25 patients, adrenal cushing syndrome 10 patients, adrenocortical carcinoma 2 patients) and perform hormonal, biochemical, imaging exam according to each disease's clinical guidelines. Based on this, the investigators will identify pathologic features, complications, and prognostic factors of each disease.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Adults, male or female aged 19 years or older
newly diagnosed with adrenal disease such as adrenal incidentaloma, pheochromocytoma, primary aldosteronism, adrenal cushing syndrome, adrenocortical carcinoma

Exclusion criteria

previous or current history of adrenal diseases
using oral or intravenous steroids
history of major depressive disorder
history of chronic alcoholics
history of any cancer with suspicious adrenal metastasis
those with acute illness (ex- patients with acute coronary syndrome within 4 weeks, acute febrile disease)

Treatment and study plan

Hormone study and Imaging study

Other

Blood (basal hormone and follow up hormone study)
Imaging examination including computed tomography scan or magnetic resonance imaging

Primary outcomes

Number of participants in remission

Time frame: Up to 10 years

Remission rate

Secondary outcomes

Complication of adrenal disease

Time frame: Up to 10 years

all complications including deaths

Sponsors and collaborators

Lead sponsor

Seoul National University Hospital

Other

Registry information

Important dates

Study start: 2018
Primary completion: 2027
Study completion: 2027
First posted: Mar 22, 2018
Registry last updated: Mar 18, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed