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OpenTrials
Completed

NCT Number: NCT03659240

Prebiotic Effects of a Polyphenol-rich Food Product

The specific aim for this project will be to investigate a cranberry beverage as a means to restore balance in terms of the relative proportions of the various bacteria that inhabit the large intestine.

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Key information

Conditions

Dysbiosis Pathologic Processes Pathological Conditions, Signs and Symptoms

Age range

18 year–45 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Nutrition and Wellness Research Center

Ames, Iowa, 50011, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • BMI 27-35 kg/m2
  • High waist circumference (men >102 cm and women >88 cm)

Exclusion criteria

  • Cigarette smoking
  • Regular intensive exercise
  • Pregnancy or lactation
  • Chronic diarrhea, constipation, or other gastrointestinal complaint
  • Diabetes mellitus, autoimmune disease, or other chronic disease known to alter the gut microbiota
  • Use of medications that affect inflammation or the gut microbiota
  • Use of prebiotics, probiotics, synbiotics, vitamins, or other dietary supplements known to affect the gut microbiota
  • Aversion to cranberries
  • Food allergies
  • Lactose intolerance
  • Vegetarianism

Treatment and study plan

Cranberry Beverage

Other

During the intervention period, research participants will consume a cranberry beverage daily.

Placebo beverage

Other

During the intervention period, research participants will consume a placebo beverage daily.

Primary outcomes

  1. Fecal microbial community composition and structure

    Time frame: Changes in the fecal microbiota will be measured after a 20-day intervention period

    We will investigate if specific bacterial taxa are stimulated by daily consumption of a cranberry beverage.

Sponsors and collaborators

Lead sponsor

Iowa State University

Other

Registry information

Important dates

Study start
2018
Primary completion
2019
Study completion
2019
First posted
Sep 6, 2018
Registry last updated
Mar 2, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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