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Completed

NCT Number: NCT02517073

Practice of Mechanical Ventilation in Patients With Severe Brain Injury in China

The mechanical ventilation strategy has changed over years worldwide. Several international researches have been conducted to study the association of the use of mechanical ventilation with clinical outcomes. In this prospective, multicenter, cross-sectional survey, the practice of mechanical ventilation among patients with severe brain injury will be investigated in 70 intensive care units in China.

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Key information

Conditions

Respiration, Artificial Pathologic Processes Pathological Conditions, Signs and Symptoms Respiration Disorders Respiratory Aspiration Respiratory Tract Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

ICU, Beijing Tiantan Hospital, Capital Medical University

Beijing, Beijing Municipality, 100050, China

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • older than 18 years
  • with severe brain injury (including severe traumatic brain injury, ischemic stroke, subarachnoid hemorrhage, spontaneous intracerebral hemorrhage, hypoxic-ischemic encephalopathy, intracranial tumor, intracranial infection and idiopathic epilepsy)
  • mechanical ventilated for at least 24 hours before the time of on-spot survey

Exclusion criteria

  • undergoing a spontaneous breathing trial (SBT) at the time of on-spot survey
  • underwent at least once SBT in the preceding 24 hours before time of on-spot survey
  • enrolled in another trial

Treatment and study plan

Primary outcomes

  1. Number of patients receiving control and assist mode of mechanical ventilation

    Time frame: During 1 hour of on-spot survey

    Control mode is defined as volume or pressure control ventilation. Assist mode is defined as synchronized intermittent mandatory ventilation and pressure support ventilation.

Secondary outcomes

  1. The settings of tidal volume, inspiratory pressure, and positive end-expiratory pressure in enrolled patients

    Time frame: During 1 hour of on-spot survey

  2. Duration of mechanical ventilation

    Time frame: 60 days after on-spot survey

  3. Number of patients liberated from mechanical ventilation

    Time frame: 60 days after on-spot survey

  4. Neurological outcome by Glasgow Outcome Scale

    Time frame: 60 days after on-spot survey

Sponsors and collaborators

Lead sponsor

Capital Medical University

Other

Registry information

Official study title

A Survey on the Practice of Mechanical Ventilation Among Patients With Severe Brain Injury in China: a Prospective Observational Study

Important dates

Study start
2015
Primary completion
2015
Study completion
2015
First posted
Aug 6, 2015
Registry last updated
Jan 28, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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