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Completed

NCT Number: NCT04154540

Posturography-Neuropathy

If the classification between hereditary and acquired neuropathy is often easy, there is no completely specific marker allowing the distinction between the two etiologies. Clinical experience suggests that hereditary neuropathies have less impact on balance and gait than the acquired neuropathies at equivalent level of impairment, but this has never been clearly demonstrated.

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Key information

Conditions

Neuropathy Demyelinating Autoimmune Diseases Autoimmune Diseases of the Nervous System Charcot-Marie-Tooth Disease Chronic Disease Congenital Abnormalities Congenital, Hereditary, and Neonatal Diseases and Abnormalities Demyelinating Diseases Disease Attributes Genetic Diseases, Inborn Hereditary Sensory and Motor Neuropathy Heredodegenerative Disorders, Nervous System Immune System Diseases Nervous System Diseases Nervous System Malformations Neurodegenerative Diseases Neuromuscular Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Peripheral Nervous System Diseases Polyneuropathies Polyradiculoneuropathy Polyradiculoneuropathy, Chronic Inflammatory Demyelinating

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Hôpital Roger Salengro, CHU

Lille, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • CMT1A for molecular-proven Group 1 (PMP22 duplication)
  • IPDC likely or defined for Group 2
  • Able to walk 10 m unassisted

Exclusion criteria

  • Neurological history other than neuropathy: epilepsy, stroke, dementia
  • Pregnant women
  • Person under guardianship or trusteeship
  • Musculoskeletal conditions other than neuropathy impairing walking abilities
  • Major comorbidity considered a contraindication by the investigator (cancer, unstable angor, etc.)

Treatment and study plan

Motion analysis

Other

Gait and posture recording

Primary outcomes

  1. Posturography (Romberg's quotient)

    Time frame: Time 0 ; single session

Secondary outcomes

  1. The Timed Up and Go test (TUG)

    Time frame: Time 0 ; single session

    It uses the time that a person takes to rise from a chair, walk three meters, turn around, walk back to the chair, and sit down.

    the scores of ten seconds or less indicate normal mobility, 11-20 seconds are within normal limits for frail elderly and disabled patients, and greater than 20 seconds means the person needs assistance outside and indicates further examination and intervention. A score of 30 seconds or more suggests that the person may be prone to falls

  2. stride length (in millimeters) parameters

    Time frame: Time 0 ; single session

    Kinematic and Kinetic parameters of the gait initiation and the stabilised gait using the optoelectronic system (VICON®)

  3. stride time (in seconde) parameters

    Time frame: Time 0 ; single session

    Kinematic and Kinetic parameters of the gait initiation and the stabilised gait using the optoelectronic system (VICON®)

  4. velocity (meter/seconde) parameters

    Time frame: Time 0 ; single session

    Kinematic and Kinetic parameters of the gait initiation and the stabilised gait using the optoelectronic system (VICON®)

  5. cadence (step/min) parameters

    Time frame: Time 0 ; single session

    Kinematic and Kinetic parameters of the gait initiation and the stabilised gait using the optoelectronic system (VICON®)

Sponsors and collaborators

Lead sponsor

University Hospital, Lille

Other

Registry information

Official study title

Study of Gait and Posture in Subacute Acquired Neuropathies and in Hereditary Neuropathies

Acronym: PONE

Important dates

Study start
2021
Primary completion
2024
Study completion
2024
First posted
Nov 6, 2019
Registry last updated
Dec 11, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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