Postural Changes in Lung Volumes in Obesity

Postural changes are known to affect normal lung volumes. A reduction in sitting to supine functional residual capacity (FRC) is well-described in non-obese subjects adopting a supine position. However, postural changes in lung volumes in the obese require further exploration. We aimed to longitudinally address the effects of weight loss on postural changes in lung volumes and pulmonary function, in obesity. We tested the hypothesis that supine reduction in FRC would be absent in morbid obesity and recovered upon weight loss.

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Key information

Conditions

Obesity Body Weight Nutrition Disorders Nutritional and Metabolic Diseases Overnutrition Overweight Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

Up to 60 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Montpellier University hospital

Montpellier, 34295, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

subjects scheduled for bariatric surgery (BMI over or equal to 40 kg/m2)

Exclusion criteria

Subjects with respiratory and cardiac history (asthma, COPD, heart failure) were excluded.

Treatment and study plan

Postural change in lung volumes: sitting to Supine

Other

Pulmonary function and arterial blood gases were assessed both prior to and after weight loss as part of pre-operative and 12-month follow-up evaluations.

Pulmonary function tests were performed both in the sitting and then in the supine position.

Primary outcomes

functional residual capacity

Time frame: baseline and one year after bariatric surgery

Secondary outcomes

lung volumes and flows

Time frame: at baseline and after bariatric surgery

Sponsors and collaborators

Lead sponsor

Association pour la Formation du Personnel à la Medecine d'Urgence

Other

Registry information

Official study title

Effect of Weight Loss on Postural Changes in Pulmonary Function : a Longitudinal Study in Morbidly Obese to Obese Subjects Following Gastroplasty

Important dates

Study start: 2005
Primary completion: 2008
Study completion: 2008
First posted: Aug 4, 2014
Registry last updated: Aug 6, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed