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Completed

NCT Number: NCT01995110

Postprandial Blood Cell Transcriptome of Normal Weight and Obese Subjects to 3 Caloric Doses of a High-fat Meal

The study will quantitatively evaluate the metabolic response of normal weight and obese subjects to three high-fat meals differing in caloric dose by analysing the postprandial blood transcriptome.

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Key information

Conditions

Obesity Body Weight Nutrition Disorders Nutritional Intervention Nutritional and Metabolic Diseases Overnutrition Overweight Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

25 year–50 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Agroscope, Bern, Canton of Bern, Switzerland

Loading trial locations.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

for normal weight subjects:

  • age 25-50
  • 20<BMI>25
  • waist circumference <94cm

Inclusion criteria

for obese subjects:

  • age 25-50
  • 30<BMI>40
  • waist circumference >102cm

Exclusion criteria

for both groups:

  • physiological or psychological diseases
  • allergies to food or intolerance to high-fat meal
  • vegetarians, vegans
  • chronic intake of drugs
  • smokers
  • diabetes mellitus type I and II
  • debiliating kidney disease
  • debiliating liver disease
  • clinically established coronary heart diseases
  • ingestion of vitamins or dietary supplements during the course of the study

Treatment and study plan

high-fat meal A

Other

Other names: high-fat meal consisting of 500 kcal

high-fat meal B

Other

Other names: high-fat meal B consisting of 1000 kcal

high-fat meal C

Other

Other names: high-fat meal C consisting of 1500 kcal

Primary outcomes

  1. blood cell transkriptome/ gene-expression

    Time frame: 0h, 2h, 4h, 6h

    • differently expressed genes between normal weight and obese subjects at baseline
    • changes in gene-expression 2, 4 and 6h after consumption

Sponsors and collaborators

Lead sponsor

Agroscope Liebefeld-Posieux Research Station ALP

Other

Registry information

Official study title

Identification of Nutritional Health Biomarkers for Metabolic Flexibility in Blood - a Randomized, Postprandial, Caloric Dose-response Strategy

Important dates

Study start
2011
Primary completion
2012
Study completion
2013
First posted
Nov 26, 2013
Registry last updated
Apr 24, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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