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Completed

NCT Number: NCT01885416

Impact of Dairy Products on Postprandial Inflammation

The study will quantitatively evaluate the systemic, postprandial inflammatory and metabolic response to the ingestion of three different meals in obese subjects. The administered meals will differ in the proportion of dairy products. Postprandial response will be monitored during 6 hours after meal consumption.

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Key information

Conditions

Inflammation Body Weight Nutrition Disorders Nutritional Intervention Nutritional and Metabolic Diseases Obesity Overnutrition Overweight Pathologic Processes Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

25 year–55 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

University Hospital, Inselspital Berne

Bern, Canton of Bern, 3010, Switzerland

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • male
  • BMI ≥ 20 kg/m2
  • age 25-55 y
  • informed consent

Exclusion criteria

  • Physiological or psychological diseases
  • Allergies to food or intolerance to high-fat meal
  • Vegetarians
  • Chronic intake of drugs
  • Smokers
  • Diabetes mellitus Type I and II
  • Debilitating kidney diseases
  • Debilitating liver diseases
  • Clinically established coronary heart diseases
  • Ingestion of vitamins or dietary supplements during the course of the study

Treatment and study plan

consumption of test meal based on dairy products

Other

consumption of high fat test meal without dairy products

Other

consumption of high fat test meal with dairy products

Other

Primary outcomes

  1. Inflammation markers in blood plasma (IL-6, TNF-alpha)

    Time frame: 0,6h

Secondary outcomes

  1. Biomarkers in blood (serum insulin, plasma glucose, GLP-1, lipids)

    Time frame: 0,1,2,4,6h

  2. Endotoxin in blood serum

    Time frame: 0,6h

Other outcomes

  1. Blood cell transcriptome

    Time frame: 0,2,4,6h

  2. blood serum metabolome

    Time frame: 0,2,4,6h

Sponsors and collaborators

Lead sponsor

Agroscope Liebefeld-Posieux Research Station ALP

Other

Collaborators

  • Insel Gruppe AG, University Hospital Bern

Registry information

Official study title

The Impact of Dairy Products on Postprandial Inflammation in Obese Males

Important dates

Study start
2013
Primary completion
2013
Study completion
2013
First posted
Jun 25, 2013
Registry last updated
Nov 19, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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