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NCT Number: NCT06752655

Postoperative Pain in Photodynamic Therapy Using Curcumin As a Photosensitizer

In endodontics, various irrigation solutions are used to achieve antibacterial efficacy within the root canal. The antibacterial effect of curcumin-containing root canal solutions, when combined with photodynamic therapy, has been demonstrated in several studies. However, no research has specifically examined their effect on postoperative pain. The aim of this study is to investigate the impact of using a curcumin solution in combination with photodynamic therapy as the final irrigation solution on postoperative pain.

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Key information

Conditions

Periapical Diseases Irrigation Solution Jaw Diseases Mouth Diseases Neurologic Manifestations Pain Pain, Postoperative Pathologic Processes Pathological Conditions, Signs and Symptoms Periodontal Diseases Photodynamic Therapy (PDT) Postoperative Complications Postoperative Dental Pain Signs and Symptoms Stomatognathic Diseases

Age range

18 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

About this study

Fifty patients were randomly assigned to two groups using a web-based program, according to the selected final irrigation procedure: curcumin-photodynamic therapy or a control group (routine root canal final irrigation with NaOCl and EDTA). The teeth will be isolated with a rubber dam, and access cavities will be created. After root canal preparation, the final irrigation procedure will be performed. Root canal treatments will then be completed, and the patients' postoperative pain levels will be recorded using follow-up forms.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • healthy patients with aged between 18-60.
  • Incisor, canine, and premolar teeth that had previously undergone root canal treatment
  • Incisor, canine, and premolar teeth with a diagnosis of chronic apical abscess or asymptomatic apical periodontitis
  • teeth with only 1 root canal
  • the patients had not used any antibiotics for 3 months before treatment

Exclusion criteria

  • the presence of a root fracture
  • teeth with any swelling
  • ankyloses,
  • periodontal pockets deeper than 4 mm.
  • teeth which a rubber dam could not be performed
  • patients with allergy to ibuprofen or ciprofloxacin were also excluded.

Treatment and study plan

Curcumin with photodynamic thearpy

Other

root canals will irrigated with final irrigation procedure: curcumin+photodynamic therapy. The teeth will be isolated with a rubber dam, and an access cavity will be created. After root canal preparation, the final irrigation procedure will be performed. Root canal treatments will be completed, and the patients' postoperative pain levels will be recorded using follow-up forms.

Control Group

Other

root canals will irrigated with routine root canal final irrigation with NaOCl and EDTA. The teeth will be isolated with a rubber dam, and an access cavity will be created. After root canal preparation, the final irrigation procedure will be performed. Root canal treatments will be completed, and the patients' postoperative pain levels will be recorded using follow-up forms.

Primary outcomes

  1. postoperative pain levels

    Time frame: one week

    postoperative pain levels will be describe using the visual analog scale (VAS). The VAS was classified using the following scale [15]: no pain (0); mild pain (1-3); moderate pain (4-6), and severe pain (7-10).

Secondary outcomes

  1. dependent variables-sex

    Time frame: one week

    The patients' genders (female or male) will be recorded, and their relationship with postoperative pain will be statistically analyzed.

  2. dependent variable-age

    Time frame: one week

    The patients' ages will be recorded as numbers, and their relationship with postoperative pain will be statistically analyzed.

  3. dependent variables-teeth number

    Time frame: one week

    The patients' tooth numbers will be recorded, and their relationship with postoperative pain will be statistically analyzed.

  4. dependent variables-smoking habit

    Time frame: one week

    The patients' smoking habits will be recorded as either "yes" or "no," and their relationship with postoperative pain will be statistically analyzed.

Study contacts

Contact information is provided by the study sponsor or research team.

Meltem Sumbullu, DDS

CONTACT

[email protected]

+90 442 231 1111

Tuğçe Sönmez, DDS

CONTACT

[email protected]

+90 442 236 0942

Sponsors and collaborators

Lead sponsor

Ataturk University

Other

Registry information

Official study title

The Effect of Photodynamic Therapy Using Curcumin As a Photosensitizer on Postoperative Pain After Non-Surgical Root Canal Retreatment: a Randomized Controlled Clinical Trial

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
Dec 31, 2024
Registry last updated
Dec 31, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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