PRF Membrane and Recovery After Periapical Surgery: A 3D Imaging Study

Inclusion criteria

• Adults aged 20-65 years, both male and female.
• Diagnosed with periapical disease, including periapical cysts or granulomas.
• Requiring periapical surgery as part of their treatment plan.
• Presenting a tooth needing endodontic surgery with periradicular lesions of strictly endodontic origin.
• Size of the bone crypt between 6 mm and 12 mm.
• Non-surgical retreatment considered unfeasible or previously failed.
• Apical root canal free from posts over a length of at least 6 mm.
• Adequate coronal restoration without coronal leakage.
• Willing and able to provide written informed consent.
• Capable of attending follow-up visits and participating in required assessments.
• Maxillary and mandibular teeth limited to the 2nd premolar to 2nd premolar regions.
• Without general medical contraindications for oral surgical procedures.

Exclusion criteria

• Patients with systemic conditions affecting healing, such as:

• • Uncontrolled diabetes mellitus.
• • Autoimmune disorders.
• • Chronic inflammatory diseases.
• Pregnant or breastfeeding individuals.
• Use of medications or therapies that may interfere with healing, including:

• • Bisphosphonates.
• • Immunosuppressants.
• • Radiotherapy.
• • Oncological therapies (e.g., chemotherapy, immunotherapy).
• Requires antibiotic prophylaxis or therapy.
• History of allergies or adverse reactions to blood-derived products.
• Neuropsychiatric disorders.
• Active infection or severe periodontal disease in the surgical area.
• Periodontal probing depths greater than 5 mm.
• Moderate to severe periodontal bone loss.
• Vertical root fractures.
• Perforation of the furcation area or root canal, except for the apical area.
• Smokers or individuals unwilling to refrain from smoking during the study period.
• Participation in another clinical trial within the last 30 days.
• Absolute or relative contraindications for surgery.