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NCT Number: NCT07574801

Postoperative Pain Following Root Canal Treatment With Bioceramic Sealers

To evaluate and compare postoperative pain and extrusion of sealers following root canal treatment using NeoSealer Flo and CeraSeal bioceramic sealers

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Key information

Conditions

Root Canal Treatment Irreversible Acute Pulpitis Neurologic Manifestations Pain Pain, Postoperative Pathologic Processes Pathological Conditions, Signs and Symptoms Postoperative Complications Signs and Symptoms

Age range

18 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Molar teeth requiring root canal treatment
  • Diagnosed with symptomatic irreversible pulpitis,
  • Patients able to understand and use the VAS scale

Exclusion criteria

  • Patients with systemic diseases affecting pain perception
  • Use of analgesics within 12 hours before treatment
  • Previously treated teeth
  • Teeth with periapical abscess or swelling

Treatment and study plan

Root canal treatment

Procedure

nanosealer flo bioceramic root canal sealer

Primary outcomes

  1. postoperative pain

    Time frame: 24 and 48 hours

    postoperative pain will be measured using a visual analogue scale ( after being introduced and discussed with the patient) at 2 time points, pain will be categorized as no pain, moderate and severe.

Secondary outcomes

  1. sealer extrusion

    Time frame: immediate postoperatively

    sealer extrusion will be measured radiographically using standardized digital periapical posttreatment radiographs via a blinded examiner and recorded as binary outcome: present/ absent.

Study contacts

Contact information is provided by the study sponsor or research team.

Heba ibrahim Mohammady

CONTACT

[email protected]

Sara Gamal Elgamal

CONTACT

[email protected]

00201094557105

Sponsors and collaborators

Lead sponsor

Cairo University

Other

Registry information

Official study title

Postoperative Pain and Sealer Extrusion Following Root Canal Treatment With Neosealer Flo and Ceraseal Bioceramic Sealers; a Randomized Clinical Trial

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
May 8, 2026
Registry last updated
May 8, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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