Postoperative Nausea and Vomiting: Ramosetron Plus Aprepitant vs Palonosetron Plus Aprepitant

The purpose of this study was to compare the antiemetic efficacy of aprepitant plus palonosetron versus aprepitant plus ramosetron in high risk patients undergoing laparoscopic cholecystectomy.

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Key information

Conditions

Postoperative Nausea and Vomiting Nausea Pathologic Processes Pathological Conditions, Signs and Symptoms Postoperative Complications Signs and Symptoms Signs and Symptoms, Digestive Vomiting

Age range

18 year–65 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

About this study

The purpose of this study was to compare the antiemetic efficacy of aprepitant plus palonosetron versus aprepitant plus ramosetron in high risk patients undergoing laparoscopic cholecystectomy.

Study is performed during 24 hours after surgery.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Non smoking, female patients, scheduled for laparoscopic cholecystectomy

Exclusion criteria

Patients with gastrointestinal disorder,
Patients with allergies to any study medication,
Patients who had received any sedatives, opioid, steroid or antiemetics within 24 h before surgery

Treatment and study plan

Aprepitant

Drug

aprepitant 80 mg is given to all patients before surgery

Palonosetron

Drug

palonosetron 0.075 mg is given to patients in the aprepitant plus palonosetron group after induction of general anesthesia

Ramosetron

Drug

ramosetron 0.3 mg is given to patients in the aprepitant plus ramosetron group after induction of general anesthesia

Primary outcomes

The Incidence of Postoperative Nausea and Vomiting

Time frame: 24 hours

The incidence of postoperative nausea and vomiting during 24 hours postoperatively

Sponsors and collaborators

Lead sponsor

Kyungpook National University Hospital

Other

Registry information

Important dates

Study start: 2014
Primary completion: 2015
Study completion: 2015
First posted: Nov 5, 2015
Registry last updated: Apr 25, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed