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Completed

NCT Number: NCT06265493

Postoperative Infectious Complications Calculator for Elderly Patients

The investigators established a first-ever convenient scoring system for clinicians to assess the risk of Postoperative infectious complications (PICs) for elderly patients. Our scoring system can aid in the early detection of potential risks for postoperative infections. Higher-score patients were more likely to experience postoperative infections.

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Key information

Conditions

Postoperative Infection Geriatrics Prediction

Age range

65 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Depatment of Anesthesiology, The First Medical Center Affiliation: Chinese PLA General Hospital

Beijing, Beijing Municipality, 100853, China

About this study

Background:

Postoperative infectious complications (PICs) are related to increased morbidity, mortality, and costs, especially in elderly patients. However, published prediction models of PICs are rarely based on elderly patients.

Objective:

The study wanted to identify practical and valuable variables that could be used to predict postoperative infections and establish a convenient scoring system for clinicians to assess the risk of such conditions in elderly patients.

Methods： Data from 2 population-based cohorts of elderly patients undergoing non-cardiac and non-neurology surgery were used to derive and validate multivariable logistic regression models. The risk prediction models were derived from 37230 patients hospitalized in the First Medical Center of the Chinese PLA General Hospital (January 2012 - August 2018). The risk prediction models were externally validated with data from a cohort of 10252 patients hospitalized in Henan Provincial People's Hospital (November 2014 to May 2022).

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • age ≥ 65 years and
  • patients undergoing surgery with anesthesia.

Exclusion criteria

  • patients undergoing neurosurgery or cardiac surgery,
  • preoperative infectious diseases, and
  • patients with ≥50% of data missing.

Treatment and study plan

Primary outcomes

  1. Postoperative Infectious Complications Calculator for Elderly Patients

    Time frame: January 2012 - August 2018

    A Derivation and External Validation of Prediction Models based on two centers large sample

Sponsors and collaborators

Lead sponsor

Weidong Mi

Other

Registry information

Official study title

Postoperative Infectious Complications Calculator for Elderly Patients--A Derivation and External Validation of Prediction Models Based on Two Centers Large Sample

Important dates

Study start
2021
Primary completion
2023
Study completion
2023
First posted
Feb 20, 2024
Registry last updated
Sep 24, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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