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Completed

NCT Number: NCT07322809

Postoperative Frailty Trajectories and One-Year Mortality in Older Surgical Patients

Frailty is a key predictor of adverse outcomes in older surgical patients, yet its longitudinal evolution and potentially reversible nature remain underexplored in perioperative settings. This study aimed to characterize postoperative frailty trajectories in older patients and to examine their association with one-year mortality, as well as factors influencing trajectory group.

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Key information

Conditions

Frailty in Older Adults All Cause Mortality Trajectory

Age range

65 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

28 Fuxing Road, Haidian District

Beijin, Beijing Municipality, 100853, China

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Aged ≥65 years;
  • Underwent elective non-cardiac, non-neurosurgical procedures;
  • Completed standardized frailty assessments both preoperatively and postoperatively.

Exclusion criteria

  • Severe dementia, language disorders, significant hearing or visual impairments, or coma;
  • Cognitive function below the Mini-Mental State Examination (MMSE) thresholds (<18 for illiterate individuals, <21 for individuals with primary education, and <25 for individuals with secondary education or higher);
  • Surgery performed under local anesthesia or monitored anesthesia care;
  • Surgical duration ≤30 minutes;
  • Missing data on postoperative complications or one-year mortality required for this study;
  • Incomplete frailty assessments at 1, 3, and 6 months after surgery.

Treatment and study plan

Primary outcomes

  1. The primary outcome was one-year all-cause mortality.

    Time frame: At the one-year postoperative follow-up.

    The primary outcome was one-year all-cause mortality, determined through structured telephone follow-up.

Sponsors and collaborators

Lead sponsor

Chinese PLA General Hospital

Other

Registry information

Official study title

Association Between Postoperative Frailty Trajectories and One-Year Mortality in Older Surgical Patients: A Prospective Longitudinal Data Study

Important dates

Study start
2020
Primary completion
2022
Study completion
2023
First posted
Jan 7, 2026
Registry last updated
Jan 9, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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