Posterior Circulation Clot Burden Score (Pc-CBS) Predicts Clinical Outcome After Acute Ischemic Stroke Related to Posterior Circulation Occlusions : An Externally Validated Radiological Score

Posterior circulation strokes (PCS) represent ~30% of all ischemic strokes, but existing prognostic tools are limited, especially for non-basilar artery occlusions. Accurate early outcome prediction may aid treatment decisions and clinical trial design. We developed and externally validated the Posterior Circulation Clot Burden Score (PC-CBS), a radiological tool to predict 3-month functional outcome in acute ischemic stroke due to posterior circulation occlusion.

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Key information

Conditions

Acute Ischemic Stroke Arterial Occlusion Disease Brain Diseases Brain Infarction Brain Ischemia Cardiovascular Diseases Central Nervous System Diseases Cerebrovascular Disorders Infarction Ischemia Ischemic Stroke Necrosis Nervous System Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Posterior Circulation Brain Infarction Stroke Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

age >18 years old
admitted within 24h from last known well
symptomatic arterial occlusion. The following arterial occlusions were eligible for inclusion: the extracranial vertebral artery between the V0 and V3 segments; the intracranial portion of the vertebral artery; the basilar artery either in its proximal, mid and/or distal segment, the P1 and/or the P2 segments of the posterior cerebral artery.

Exclusion criteria

simultaneous clinical and/or radiological strokes in the posterior and anterior circulation

Treatment and study plan

Assessment of cervico-cerebral arterial occlusion pattern

Diagnostic Test

Assessment of cervico-cerebral arterial occlusion pattern for the development of a radiological score

Primary outcomes

Modified rankin scale at three months

Time frame: 3 months

Sponsors and collaborators

Lead sponsor

Centre Hospitalier Universitaire Vaudois

Other

Collaborators

Aristotle University Of Thessaloniki
Azienda Ospedaliero-Universitaria di Modena
Boston University
EOC Lugano CH
Hebrew University of Jerusalem
Hospital Vall d'Hebron
Hospital de Egas Moniz
Hôpital Rothschild
IRCCS Istituto delle Scienze Neurologiche di Bologna
Insel Gruppe AG, University Hospital Bern
Ludwig-Maximilians - University of Munich
Medical University Innsbruck
Medical University of Graz
Medical University of Vienna
Michigan State University
Ospedale Policlinico San Martino
Technische Universität Dresden
The University of Texas Health Science Center, Houston
University Hospital Heidelberg
University Hospital, Basel, Switzerland
Università degli Studi di Brescia

Registry information

Acronym: PC-CBS

Important dates

Study start: 2003
Primary completion: 2023
Study completion: 2025
First posted: Aug 14, 2025
Registry last updated: Aug 14, 2025

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This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed