Intra-arterial Thrombolysis After Successful Thrombectomy for Acute Ischemic Stroke in the Posterior Circulation (IAT-TOP)

Inclusion criteria

• Symptoms and signs compatible with ischemia in the posterior circulation;
• Basilar artery occlusion or vertebral artery occlusion without antegrade flow to the basilar artery confirmed by computed tomographic angiography (CTA)/ magnetic resonance angiography (MRA)/ digital subtraction angiography (DSA);
• Age ≥18 years and ≤80 years;
• Premorbid mRS ≤1;
• National Institutes of Health Stroke Score (NIHSS) ≥6 at admission；
• PC-ASPECTS on CT/CTA-Source Images/MRI-DWI 6-10；
• Treated with endovascular thrombectomy (EVT) resulting in an eTICI score ≥2b50 at end of the procedure；
• Time from symptom onset to randomization<24 hours, including wake-up stroke and unwitnessed stroke; Time of onset of symptoms is defined as "last known well" (LKW) if symptoms are not witnessed or time of estimated basilar artery occlusion (defined as the time of sudden onset of basilar artery stroke symptoms, with no consideration of any preceding minor prodromal symptoms, as adjudicated by two neurologists) if symptoms are witnessed;
• Informed consent obtained from the patient or his/her legal representative.

Exclusion criteria

• Contraindication to Intravenous Thrombolysis (except time to treatment);
• Complete clinical recovery in the angiography suite by end of MT procedure;
• More than 3 passes of thrombectomy device;
• Dissection of occluded artery or intraoperative bleeding on DSA after thrombectomy;
• Patients in sedation and intubated patients could not be included if baseline NIHSS is not obtained by a neurologist or emergency physician prior to sedation or intubation;
• Seizures at stroke onset which would preclude obtaining a baseline NIHSS;
• Bilateral dilated pupils;
• Severe contrast allergy or absolute contraindication to iodinated contrast;
• Systolic pressure >185 mmHg or diastolic pressure >110 mmHg, and cannot be controlled by antihypertensive drugs;
• Blood glucose <50 mg/dl (2.8 mmol/L) or >400 mg/dl (22.2 mmol/L);
• Platelet <50*10^9/L, or aPTT >40 s, or PT >15 s;
• Known genetic or acquired bleeding diathesis, deficiency of anticoagulant factors, or oral anticoagulant drugs and INR > 1.7, or treated with direct oral anticoagulant agents in the prior 48 hours;
• Known Severe renal Failure as defined by a serum creatinine > 3.0 mg/dl (or 265.2 μmol/l) or glomerular Filtration Rate [GFR] <30, or patient requires hemodialysis or peritoneal dialysis;
• Patients that cannot complete 90-day follow-up (e.g. no fixed residence, overseas patients, etc.);
• Presumed vasculitis or septic embolization;
• Suspicion of aortic dissection;
• The patient has neurological disease or mental disorder before onset, which affects the assessment of the condition;
• Females who are pregnant or in lactation;
• Participating in other clinical trials that could confound the evaluation of the study;
• Other circumstances that the investigator considers inappropriate for participation or may pose a significant risk to patients.