Posterior Cingulate Function in Persons With Risk Factors for Alzheimer's Disease

The purpose of this study is to use fMRI techniques to explore a certain part of the brain associated with Alzheimer's disease known as the posterior cingulate. Determining the functionality of this brain region may help us diagnose AD more accurately, thus allowing earlier treatment.

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Key information

Conditions

Magnetic Resonance Imaging Adult Children Alzheimer Disease Alzheimer's Disease Brain Diseases Central Nervous System Diseases Dementia Mental Disorders Nervous System Diseases Neurocognitive Disorders Neurodegenerative Diseases Risk Tauopathies

Age range

55 year–65 year

Sex eligibility

All sexes

Study type

Observational

Primary location

University of Wisconsin - Wisconsin Comprehensive Memory Program

Madison, Wisconsin, 53792, United States

About this study

The posterior cingulate is a key brain region suggested by recent studies to be affected in people at risk for Alzheimer's Disease (AD). Because the PC is affected very early in the course of AD and the region may have reduced function even prior to the onset of symptoms, further understanding of its functional role and its relationship to other brain regions may be helpful in detecting AD earlier and in monitoring disease progression and treatment. This project examines the role of the PC and its connections to other brain regions using functional magnetic resonance imaging (fMRI), a technique that allows us to examine the brain at work during tests of memory and decision-making. The main goal is to see if functional connections between brain regions are modulated by risk for AD.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Cognitively healthy
(Controls Only) Parents survived past age 70 and did/do not have memory problems.

Exclusion criteria

Claustrophobia
Metallic or electronic implants

Sponsors and collaborators

Lead sponsor

University of Wisconsin, Madison

Other

Collaborators

VA Office of Research and Development

Registry information

Acronym: PC

Important dates

Study start: 2005
Study completion: 2007
First posted: May 24, 2007
Registry last updated: Oct 5, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed