fMRI of Vulnerable Brain Regions in Persons at Risk for Alzheimer's Disease

The purpose of this study is to investigate the organization of memory and develop future methods for early detection of AD. Using functional magnetic resonance imaging (fMRI), we examine the responsiveness of the brain to memory tasks, specifically focusing on regions of the brain (the mesial temporal lobe and posterior cingulate) that are known to be involved in early stages of Alzheimer's disease (AD). Of interest are differences in brain activation between people with and without a family history of AD and other risk factors.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Magnetic Resonance Imaging Adult Children Alzheimer Disease Alzheimer's Disease Brain Diseases Central Nervous System Diseases Dementia Mental Disorders Nervous System Diseases Neurocognitive Disorders Neurodegenerative Diseases Risk Tauopathies

Age range

40 year–85 year

Sex eligibility

All sexes

Study type

Observational

Primary location

University of Wisconsin - Wisconsin Comprehensive Memory Program

Madison, Wisconsin, 53792, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

MCI Group: Diagnosis of mild cognitive impairment
AD Family History Group: Confirmed family history of Alzheimer's and concurrent enrollment in the Wisconsin Registry for Alzheimer's Prevention (WRAP)
Control Groups: Cognitively healthy and both parents survived past age 70 with no memory problems

Exclusion criteria

Claustrophobia
Metallic or electronic implants or devices that are not MRI-safe

Sponsors and collaborators

Lead sponsor

University of Wisconsin, Madison

Other

Collaborators

National Institute on Aging (NIA)
National Institutes of Health (NIH)

Registry information

Acronym: ALZ

Important dates

Study start: 2003
Primary completion: 2011
Study completion: 2011
First posted: May 24, 2007
Registry last updated: Oct 27, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed