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Completed

NCT Number: NCT04364061

Post Exercise Substrate Oxidation, Appetite and Energy Intakes in Overweight/Obese Postmenopausal Women (EScAPE)

High-intensity interval exercise (HIIT), as compared to moderate intensity continuous training (MICT), is a time-efficient strategy to decrease total and abdominal fat mass (FM). However, the mechanisms underlying such adaptations are not yet elucidated and research are still needed to establish the optimal HIIT according to subject characteristics. The aim of this study was to compare acute HIIE and MICE cycling exercises on enjoyment, post-exercise substrate oxidation, appetite and energy intakes over 24h in postmenopausal women with overweight or obesity. It is hypothesized that compared with the traditional MICE, HIIE could favor greater enjoyment, higher 2h-post-exercise fat oxidation and a similar energy intakes over 24h despite different post-exercise appetite perceptions.

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Key information

Conditions

Overweight Body Weight Nutrition Disorders Nutritional and Metabolic Diseases Overnutrition Pathological Conditions, Signs and Symptoms Postmenopausal Signs and Symptoms

Age range

50 year–75 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

CREPS Auvergne Rhône-Alpes / Vichy

Bellerive-sur-Allier, Allier, 03321, France

About this study

The aim of this study was to compare acute HIIE and MICE cycling exercises on enjoyment, post-exercise substrate oxidation, and appetite and energy intakes over 24h in postmenopausal women with overweight or obesity.

Using a randomized crossover design, 12 postmenopausal women completed 3 cycling exercises at 6-days intervals:

i) Moderate Intensity Continuous Exercise (MICE) which consisted of 35 min cycling at 60-65% theorical Peak Heart Rate (thPHR) ii) High Intensity Interval Exercise 1 (HIIE 1) 60 cycles of speeding up for 8 s at 80-90%thPHR followed by pedaling slowly for 12 s (20min) iii) High Intensity Interval Exercise 2 (HIIE 2) which consisted of repeated 10 x 1min at 80-90% thPHR followed by pedaling slowly for 1min.

Substrate oxidation (CHO and FAT) were measured at rest and 2h- post exercise. Enjoyment, perceived exertion and appetite were recorded and post-exercise energy intakes were assessed over 24h.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • postmenopausal women (spontaneous amenorrhea for at least 12 months)
  • with overweight or obesity (BMI > 25 kg/m2 and ≤ 40 kg/m2)

Exclusion criteria

  • medical contraindications to intense physical activity,
  • painful joints,
  • taking hormone replacement therapy,
  • taking B-blockers.

Treatment and study plan

Moderate intensity continuous exercise

Other

Participant completed a moderate intensity continuous cycling exercise (MICE) during 35 min at 60-65% thPHRmax

High-Intensity Interval Exercise (1)

Other

Participant completed a high-intensity interval cycling exercise (HIIE 1) during 20min with 60 cycles of speeding up for 8s and pedaling slowly for 12s at 80-90% thPHRmax

High-Intensity Interval Exercise (2)

Other

Participant completed a high-intensity interval cycling exercise (HIIE 2) during 20min with 10 x 1-min bouts at 80-90% thPHRmax, separated by 1-min recovery bouts

Primary outcomes

  1. Post-exercise (2 hours) CHO and FAT oxidation

    Time frame: 2 hours post-exercise

    CHO and FAT oxidation were measured after each modality with indirect calorimetry during 2 hours post-exercise

Secondary outcomes

  1. Enjoyment

    Time frame: Immediately post-exercise

    Perceive enjoyment evaluated with Physical Activity Enjoyment Scale (PAES) for each modalities. The total scores of PAES are between 18 and 126 with the higher scores indicating greater enjoyment.

  2. Rate Perceive Exertion (RPE)

    Time frame: During exercise (5-10-15 and 20 minutes for HIIE1 and 2 ; 9-18-27 and 35 minutes for MICE) which corresponds at 25-50-75 and 100% of bout completion.

    RPE evaluated with adapted Borg's Scale during exercise for each modalities

  3. Appetite

    Time frame: Before, immediately post-exercise, 60 minutes and 120 minutes post-exercise

    The validated 100 millimeters Visual Analogue Scale (VAS) was used to assess the subjective appetite at 4 time points: before, immediately post-exercise, 60 minutes and 120 minutes post-exercise. This scale comprised four questions anchored with words representing the opposing extreme states of desire to eat, hunger, fullness and prospective food consumption. The score of each question are between 0 and 100.

  4. Energy intakes

    Time frame: 24 hours post-exercise

    Estimated energy intakes using dietary questionnaires

Sponsors and collaborators

Lead sponsor

Laboratoire des Adaptations Métaboliques à l'Exercice en conditions Physiologiques et Pathologiques

Other

Collaborators

  • CREPS Auvergne Rhône-Alpes / Vichy

Registry information

Official study title

Comparison of Acute Cycling Modalities on Enjoyment, Post Exercise Substrate Oxidation, Appetite and Energy Intakes Over 24h in Postmenopausal Women With Overweight or Obesity

Acronym: EScAPE

Important dates

Study start
2019
Primary completion
2020
Study completion
2020
First posted
Apr 27, 2020
Registry last updated
Apr 28, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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