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NCT Number: NCT06697743

Post Bariatric Surgery Acute Kidney Injury: Incidence and Risk Factors

Bariatric surgery is the most effective means of inducing and maintaining sustained weight loss. Apart from the weight loss effect, bariatric surgery leads to the remission of chronic metabolic disorders such as type 2 diabetes (T2D) and hypertension . Recent studies have shown that bariatric surgery improves renal perfusion and glomerular function and reduces inflammatory markers which can lead to an improvement of microalbuminuria and proteinuria However, acute kidney injury (AKI) can complicate the postoperative course after bariatric surgery. The etiology of AKI after bariatric surgery can be multifactorial and complex in obese population . The preexisting factors such as diabetes, hypertension, and CKD in these patients can additionally worsen the renal insult during the postoperative period . Postoperative AKI is associated with increase morbidity and mortality especially in cases of severe AKI that requires dialysis support . Identifying the high-risk patients for development of postoperative AKI would prevent renal injury. Our aim was to study the incidence and etiology of postoperative AKI after bariatric surgery . Causes of post bariatric surgery AKI include . Pre renal causes :dehydration ( repeated vomiting and diarrhoea)which are common complications post bariatric surgery , haemorrhagic shock (from the site of anastomosis , ulcer ) , septic shock ( leakage , pneumonia) , hypotension and respiratory depression secondary to narcotic overdose. Rena causes: contract induced nephropathy after using CT scan guided drainage of intra abdominal collection post operative, Rhabdomylosis , drug induced nephropathy e.g :using of IV vancomycin for sepsis in ICU .. many causes can lead to AkI post bariatric surgery but the common two causes are dehydration and sepsis .

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Key information

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

  • Inclusion criteria:
  • Age more than 18 years old undergo bariatric surgery .
  • BMI ≥30 : ( BMI = weight in kg / height in m²)
  • Exclusion criteria:
  • previous kidney diseases(AKI , CKD) .
  • patients unfit for surgery e.g ( comorbidities : CHD , LCF ) 3. Drugs : (ACE-I , ARBs, and NSAIDS)

Treatment and study plan

Primary outcomes

  1. incidence

    Time frame: Baseline

    assess the incidence of postoperative AKI after bariatric surgery .

  2. Risk factors

    Time frame: Baseline

    assess the risk factors of postoperative AKI after bariatric surgery

Secondary outcomes

  1. duration of hospitalization

    Time frame: Baseline

    Assess the duration of hospitalization, and it's relation with the incidence of AKI

  2. readmission

    Time frame: Baseline

    Assess the duration of readmission within 30 d after surgery and it's relation with the incidence of AKI

Study contacts

Contact information is provided by the study sponsor or research team.

Georgina Tharwat Abdelmasih, Master

CONTACT

[email protected]

[email protected] ext. +20 1203254445

Sponsors and collaborators

Lead sponsor

Georgina Tharwat Abdelmasih

Other

Collaborators

  • Assiut University

Registry information

Important dates

Study start
2024
Primary completion
2026
Study completion
2027
First posted
Nov 20, 2024
Registry last updated
Nov 20, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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