ABCG8, UGT1A1 and Gallstone Disease After Bariatric Surgery

The goal of this observational genetic case-control study is to learn whether two specific genetic variants in ABCG8 and UGT1A1 are associated with gallstone disease after bariatric surgery. The study includes adults who have previously undergone bariatric surgery.

The main questions it aims to answer are whether the ABCG8 D19H variant and the UGT1A1 rs6742078 variant are associated with an increased risk of gallstone disease requiring cholecystectomy after bariatric surgery.

Researchers will compare patients who underwent bariatric surgery and later had their gallbladder removed because of gallstone disease with patients who underwent bariatric surgery but did not develop gallstone disease or undergo cholecystectomy during follow-up.

Participants will provide one blood sample for targeted genetic analysis and complete questionnaires about health, previous surgery, medication use, family history, and gastrointestinal quality of life. Relevant clinical information will also be collected from medical records.

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Key information

Conditions

Gallstone Disease Bariatric Surgery Biliary Tract Diseases Cholecystectomy Cholelithiasis Digestive System Diseases Genetics Metabolic Surgery

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Bariatric surgery

Exclusion criteria

Gallstone disease or cholecystectomy prior to bariatric surgery

Treatment and study plan

Blood sampling

Diagnostic Test

Targeted genetic analysis of the ABCG8 D19H variant and the UGT1A1 rs6742078 variant using a blood sample.

Primary outcomes

ABCG8 carrier status

Time frame: 3 years

The primary outcome is the association between ABCG8 D19H carrier status and gallstone-related cholecystectomy after bariatric surgery. Cases are participants who underwent bariatric surgery and subsequently underwent cholecystectomy due to gallstone disease. Controls are participants who underwent bariatric surgery and did not undergo cholecystectomy or develop gallstone disease during follow-up. The association will be estimated by comparing genotype frequencies between cases and controls.

Secondary outcomes

Association Between UGT1A1 rs6742078 Carrier Status and Gallstone-Related Cholecystectomy After Bariatric Surgery

Time frame: 3 years

Association between UGT1A1 rs6742078 carrier status and gallstone-related cholecystectomy after bariatric surgery, estimated by comparing genotype frequencies between cases and controls.

Study contacts

Contact information is provided by the study sponsor or research team.

Benjamin Petersen, M.D

CONTACT

[email protected]

+45 7918 5714

Sponsors and collaborators

Lead sponsor

Esbjerg Hospital - University Hospital of Southern Denmark

Other

Collaborators

Odense University Hospital
University of Southern Denmark

Registry information

Official study title

ABCG8, UGT1A1 and Gallstone Disease After Bariatric Surgery: A Genetic Study

Important dates

Study start: 2026
Primary completion: 2029
Study completion: 2029
First posted: Jul 14, 2026
Registry last updated: Jul 17, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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