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Completed

NCT Number: NCT01878721

Positron Emission Tomography of Infection and Vasculitis

The purpose of this study is to evaluate the value of positron emission tomography/computed tomography in various inflammatory conditions caused by bacterial infection or vasculitis. Glucose analog FDG is sensitive to detect inflammation foci but we hypothesize that other imaging agents such as PK11195 and Ga-citrate may have added value in certain applications.

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Key information

Conditions

Infection Cardiovascular Diseases Infections Vascular Diseases Vasculitis

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Turku University Hospital

Turku, FI-20521, Finland

About this study

The purpose of this study is to evaluate the value of PET/CT in various inflammatory conditions caused by bacterial infection or vasculitis. Our aim is to:

  • investigate whether FDG (18F-2-fluoro-2-deoxy-D-glucose fluorodeoxyglucose) PET/CT and 68Ga-(Gallium-68) citrate PET/CT enable the early and accurate detection of metastatic infection foci in Staphylococcus aureus bacteremia.
  • study the usefulness of FDG PET/CT in detection of endovascular infection in bacteremia caused by Salmonella spp.
  • find an optimal FDG PET/CT protocol for detection of infectious endocarditis and metastatic infection foci related to endocarditis.
  • study the value of FDG PET/CT in the diagnosis of infection of pacemaker or implantable cardioverter defibrillator.
  • investigate the usefulness of FDG PET/CT, 68Ga-citrate PET/CT, and 11C- (carbon-11) translocator protein ligand (PK11195) PET/CT in diagnosis of vasculitis and in imaging of the magnitude of the vascular changes.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Adults with

  • Staphylococcus aureus bacteremia or
  • Salmonella spp. bacteremia or
  • infective endocarditis or
  • infection of pacemaker or implantable cardioverter defibrillator or
  • vasculitis

Exclusion criteria

  • underage, pregnant, breastfeeding, handicapped or prisoner

Treatment and study plan

PET/CT

Radiation

positron emission tomography/computed tomography

Primary outcomes

  1. Detection of infection or vasculitis in PET images

    Time frame: within 1 week after starting the treatment

Secondary outcomes

  1. Standardized uptake value of PET imaging agent at the site of infection or vasculitis

    Time frame: within 1 week after starting the treatment

Sponsors and collaborators

Lead sponsor

Turku University Hospital

Other Gov

Registry information

Official study title

Positron Emission Tomography of Infection and Vasculitis (PETU)

Acronym: PETU

Important dates

Study start
2011
Primary completion
2021
Study completion
2021
First posted
Jun 17, 2013
Registry last updated
Oct 22, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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