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NCT Number: NCT02463006

Porous and Non-porous Bone Grafts in Intra-bony Periodontal Defects

Till date, no study has been reported in the literature where porous bioactive glass was used for the management of periodontal osseous defects. In this context, the present study is designed to assess the efficacy of the porous variant of bioactive glass and compare with that of nonporous variant using cone beam computed tomography.

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Key information

Conditions

Periodontal Disease Mouth Diseases Periodontal Diseases Stomatognathic Diseases

Age range

18 year–55 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 2 / Phase 3

About this study

OBJECTIVES:

  • To evaluate clinically the periodontal healing with Porous variant of Bioactive Glass placed in the intra bony defects at an interval of 6 months.
  • To evaluate clinically the periodontal healing with Non Porous variant of Bioactive Glass placed in the intra bony defects at an interval of 6 months.
  • To evaluate the radiographic changes in the intra bony defect grafted with Porous variant of Bioactive Glass at baseline and an interval of 6 months.
  • To evaluate the radiographic changes in the intra bony defect grafted with Non Porous variant of Bioactive Glass at baseline and an interval of 6 months.
  • To compare clinically soft tissue healing for sites grafted with Porous variant of Bioactive Glass and sites grafted with Non Porous variant of Bioactive Glass in the treatment of periodontal intra bony defects at an interval of 6 months.
  • To compare the radiographic changes for sites grafted with Porous variant and sites grafted with Non Porous of Bioactive Glass in the treatment of periodontal intra bony defects at an interval of 6 months.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • INCLUSION CRITERIA
  • Age: 18-55 years.
  • Probing Depth >5mm.

Exclusion criteria

  • EXCLUSION CRITERIA
  • History of periodontal treatment last six months.
  • Bleeding disorders.
  • Gross oral pathology.

Treatment and study plan

Porous variant of Bioactive Glass.

Drug

Flap surgery with Porous variant of Bioactive Glass.

Non porous variant of Bioactive Glass.

Drug

Flap surgery with non-Porous variant of Bioactive Glass.

Primary outcomes

  1. Change in relative attachment loss

    Time frame: 6 months

Secondary outcomes

  1. Change in probing depth

    Time frame: 6 months

  2. Change in plaque index

    Time frame: 6 months

Sponsors and collaborators

Lead sponsor

Dr. D. Y. Patil Dental College & Hospital

Other

Registry information

Official study title

Comparative Evaluation of Porous and Non Porous Variants of Bioactive Glass in the Treatment of Periodontal Intrabony Defects: A Cone Beam Computed Tomography Analysis

Important dates

Study start
2014
Primary completion
2014
Study completion
2015
First posted
Jun 4, 2015
Registry last updated
Jun 4, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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