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Completed

NCT Number: NCT07004127

Pneumocystis in Patients Over 75 Year

Pneumocystis pneumonia is an infectious disease caused by Pneumocystis jirovecii that affects the lung parenchyma preferentially. Historically described in an immunocompromised population through HIV.

Worldwide, the profile of patients affected by this pathology is changing due to two main factors:

* The sustainable stabilization of HIV patients. * The emergence of new risk factors of immunosuppression. The geriatric population is particularly affected by these risk factors, increasing the incidence of pneumocystis in this population, which does not have HIV (solid cancer, hemopathy, immunosuppressive treatments, etc.).

There is currently no work specifically studying pneumocystis in this age group. The main objective of this study is to describe the clinical, biological and therapeutic data of a cohort of geriatric patients with pneumocystis, not carrying HIV, from January 1, 2010 to December 31, 2021, in all the centers surveyed.

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Key information

Conditions

Pneumocystis Bacterial Infections and Mycoses Infections Lung Diseases Lung Diseases, Fungal Mycoses Pneumocystis Infections Pneumonia Pneumonia, Pneumocystis Respiratory Tract Diseases Respiratory Tract Infections

Age range

75 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

CHU de NIMES

Nîmes, 30029, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patient > or equal to 75 years of age
  • Microbiological diagnosis:
  • Direct examination with standard stain, finding trophozoite and/or P.jirovecii cyst (BAL or induced sputum) And/or
  • Direct examination with immunofluorescence, finding trophozoite and/or P.jirovecii cyst (BAL or induced sputum)
  • And/or
  • Positive PCR (BAL, sputum, nasopharyngeal swab or blood) and CT < 35
  • Absence of HIV infection
  • Hospitalization in French hospitals between 2010 and 2021

Non-inclusion criteria

  • Opposition of the patient to participate to the study

Treatment and study plan

Primary outcomes

  1. Clinical data

    Time frame: From DAY 0 to end of treatment

    description of clinical data

  2. Therapeutic data

    Time frame: From DAY 0 to end of treatment

    description of treatment provide to treat pneumocystosis

  3. Biological data

    Time frame: From DAY 0 to end of treatment

    Analysis of biological data realized during follow up

Sponsors and collaborators

Lead sponsor

Centre Hospitalier Universitaire de Nīmes

Other

Registry information

Official study title

Pneumocystis in Non-HIV Patients Over 75 Years Old: Epidemiological, Diagnostic, Microbiological and Therapeutic Characteristics

Acronym: C_PAPY

Important dates

Study start
2010
Primary completion
2023
Study completion
2023
First posted
Jun 4, 2025
Registry last updated
Jun 4, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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