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Completed

NCT Number: NCT01900366

Pilot Study for Noninvasive Spectroscopic Detection of Adipose Tissue Inflammation in Obesity

This study will test the potential of two techniques using light properties of adipose tissue to diagnose crown-like structures and inflammation to be compared with pathologic examination of adipose tissue biopsies from ongoing clinical studies.

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Key information

Conditions

Obesity Body Weight Nutrition Disorders Nutritional and Metabolic Diseases Overnutrition Overweight Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

18 year–70 year

Sex eligibility

All sexes

Study type

Observational

Primary location

The Rockefeller University

New York, 10065, United States

About this study

Adipose tissue (fat) inflammation is emerging as an important harbinger of disease development including Type 2 diabetes, heart disease and potentially cancer. The hallmark feature of adipose tissue inflammation is the crown-like structure, a dying fat cell surrounded by immune cells attempting to clear the damage. Current methods for detecting adipose tissue inflammation rely on invasive procedures such as fat biopsies. We propose developing methods that use the light reflection properties of inflamed adipose tissue as a potential non-invasive method to detect adipose tissue inflammation.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

-Subjects currently enrolled in a current Rockefeller University study who will be undergoing adipose tissue biopsies as part of the study protocol

Exclusion criteria

-History of any skin disease

Treatment and study plan

Fat Biopsy

Procedure

Fat biopsy

Primary outcomes

  1. Classification of adipose tissue as healthy or inflamed by Raman Spectroscopy

    Time frame: 1 day

    Classification of adipose tissue as healthy or inflamed by Raman Spectroscopy

Secondary outcomes

  1. Steady state oxygenation at the site of tissue biopsy by Diffuse Reflectance Spectroscopy

    Time frame: 1 day

    Steady state oxygenation at the site of tissue biopsy by Diffuse Reflectance Spectroscopy

Sponsors and collaborators

Lead sponsor

Rockefeller University

Other

Collaborators

  • Weill Medical College of Cornell University

Registry information

Important dates

Study start
2013
Primary completion
2016
Study completion
2016
First posted
Jul 16, 2013
Registry last updated
Sep 19, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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