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NCT Number: NCT07248124

Pilot Study, Aimed at Describing in Myography, the Collapse of the Muscular Response Visualized in the Scratch Collapse Test, in Carpal Tunnel Syndrome.

The Scratch Collapse Test (SCT) is a neurocutaneous reflex used to detect peripheral nerve compression in nerve tunnel syndromes. It first involves applying a sensory stimulus to the skin over the suspected nerve compression point, then bilaterally testing the strength of a specific muscle in the patient. Compression is then manifested by a transient loss of strength in the muscle on the affected side, while it is preserved on the healthy side. This loss of strength is transient and disappears after a few seconds. This test can be performed during a patient's clinical examination, with the physician assessing strength or, conversely, muscle collapse. However, while several articles have described the relevance of this test, as well as its sensitivity and specificity, no study has specifically investigated and measured this observed loss of eccentric muscle tone and its unilateral and transient nature, even though the phenomenon of CSP (cutaneous silent period) has been described.

We therefore propose to analyze the myographic tracing obtained in patients diagnosed with unilateral carpal tunnel syndrome. A transient loss of muscle tone is expected by selective needle myography on the pathological side after cutaneous sensory stimulation of the wrist, while cutaneous sensory stimulation on the healthy side does not alter the tracings obtained by myography.

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Key information

Conditions

Carpal Tunnel Syndrome (CTS) Carpal Tunnel Syndrome Cumulative Trauma Disorders Median Neuropathy Mononeuropathies Nerve Compression Syndromes Nervous System Diseases Neuromuscular Diseases Peripheral Nervous System Diseases Sprains and Strains Wounds and Injuries

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patient over 18 years old
  • Patient with clinical unilateral carpal tunnel syndrome diagnosed by history, clinical examination and electromyography,
  • Patient who has been informed and has given their free, informed, and written consent,
  • Patient affiliated with or beneficiary of a social security scheme.

Exclusion criteria

  • Other associated canal syndrome on either side (ulnar, defilement, lacertus),
  • Rotator cuff pathology, insufficiency or rupture of the infraspinatus,
  • Associated cervical pathology,
  • Neuropathy, central or peripheral neurological disease,
  • Diabetic patient,
  • Patient with cognitive impairments that prevent the understanding of the study information,
  • Refusal to participate in the study,
  • Pregnant, parturient, or breastfeeding woman,
  • Patient under legal protection,
  • Patient not receiving health protection,
  • Protected patient: adult under guardianship, curatorship, or other legal protection, deprived of liberty by judicial or administrative decision

Treatment and study plan

electromyograph

Procedure

This examination uses electrodes placed along the path of the median nerve to measure the transmission of nerve impulses (conduction studies). It is performed on both hands to compare the results.

Scratch collapse test

Diagnostic Test

The Scratch Collapse Test (SCT) is a neurocutaneous reflex used to detect peripheral nerve compression in nerve canal syndromes. It involves first performing a sensory stimulus on the skin at the suspected nerve compression site, then bilaterally testing the strength of a specific muscle in the patient. Compression is then manifested by a transient loss of strength in the muscle on the affected side, while it is preserved on the stimulated side.

Primary outcomes

  1. Evolution of the myographic tracings

    Time frame: one day

    Evolution of the myographic tracings (of the infraspinatus muscle) of the pathological arm immediately after ipsilateral stimuli compared to the basic tracings (before stimuli) of the pathological arm and evolution of the myographic tracings of the pathological arm 20 seconds after ipsilateral stimuli compared to the basic tracings (before stimuli) of the pathological arm.

Study contacts

Contact information is provided by the study sponsor or research team.

Vincent Martinel, Dr

CONTACT

[email protected]

0033562563895

Sponsors and collaborators

Lead sponsor

Elsan

Other

Registry information

Official study title

Pilot Study, Aimed at Describing in Myography, the Collapse of the Muscular Response Visualized in the Scratch Collapse Test, in Carpal Tunnel Syndrome

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Nov 25, 2025
Registry last updated
Nov 25, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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